NEW WOSULIN 30/70 PENFILL 3 ML

How NEW WOSULIN 30/70 PENFILL 3 ML Works

• NEW WOSULIN 30/70 PENFILL 3 ML is a premixed insulin formulation containing both rapid-acting (30%) and intermediate-acting (70%) human insulin. This combination is designed to provide both a quick burst of insulin to cover mealtime blood sugar spikes and a longer-lasting background insulin to manage blood sugar levels between meals and overnight. The rapid-acting component helps to control post-meal glucose elevations, while the intermediate-acting component ensures a steady supply of insulin to meet the body's basal needs.
• The rapid-acting insulin, also known as regular insulin, works by allowing glucose to enter cells for energy production. When you eat, carbohydrates are broken down into glucose, which enters the bloodstream. Insulin signals to cells, primarily in the liver, muscle, and fat tissues, to absorb this glucose. By facilitating glucose uptake, rapid-acting insulin helps to lower blood sugar levels quickly after a meal. Its effect starts within 30 minutes, peaks in 2-4 hours, and lasts for about 4-8 hours.
• The intermediate-acting insulin, typically NPH (Neutral Protamine Hagedorn) insulin, is modified to prolong its action. Protamine, a protein, is added to regular insulin, which slows down its absorption from the injection site. This results in a delayed onset and a longer duration of action compared to rapid-acting insulin. NPH insulin starts working in 1-2 hours, peaks in 4-12 hours, and lasts for up to 18-24 hours, providing a basal insulin level to help control blood sugar between meals and overnight.
• When NEW WOSULIN 30/70 PENFILL 3 ML is injected subcutaneously, the insulin is absorbed into the bloodstream. The rapid-acting component starts working quickly to manage post-meal glucose, while the intermediate-acting component gradually releases insulin to maintain stable blood sugar levels throughout the day and night. This combination helps mimic the body's natural insulin release pattern, providing both prandial (mealtime) and basal (background) insulin coverage.
• The specific ratio of 30/70 allows for convenient administration and helps to simplify diabetes management. It reduces the number of injections required compared to using separate rapid-acting and intermediate-acting insulins. However, the dosage and timing of NEW WOSULIN 30/70 PENFILL 3 ML must be carefully tailored to an individual's needs, considering factors such as diet, exercise, and overall health status. Regular blood glucose monitoring is essential to ensure optimal glycemic control and to adjust insulin doses as needed, under the guidance of a healthcare professional.

Like all medicines, NEW WOSULIN 30/70 PENFILL 3 ML can cause side effects, although not everybody gets them. **Common side effects (may affect up to 1 in 10 people):** * Hypoglycemia (low blood sugar): This is the most common side effect. Symptoms can include sweating, shakiness, anxiety, rapid heartbeat, hunger, dizziness, headache, blurred vision, and difficulty concentrating. Severe hypoglycemia can lead to unconsciousness and, in rare cases, be fatal. * Local reactions at the injection site: Redness, swelling, itching, or pain at the injection site. **Uncommon side effects (may affect up to 1 in 100 people):** * Lipodystrophy: This refers to changes in fat tissue at the injection site. It can either be lipoatrophy (loss of fat) or lipohypertrophy (thickening of fat tissue). This can affect insulin absorption. * Edema: Swelling, particularly in the ankles and feet, due to fluid retention. **Rare side effects (may affect up to 1 in 1,000 people):** * Allergic reactions: These can be localized (e.g., rash, itching) or generalized (e.g., whole-body rash, difficulty breathing, wheezing, rapid heartbeat, sweating). Severe allergic reactions can be life-threatening. **Very rare side effects (may affect up to 1 in 10,000 people):** * Diabetic neuropathy (nerve damage). * Visual Disturbance: Change in refractive power or blurred vision **Other possible side effects:** * Weight gain * Injection site reactions (itching, pain, bruising etc) **If you experience any side effects, even those not listed above, talk to your doctor, pharmacist, or diabetes educator. It is important to report side effects so that more information can be gathered about the safety of this medicine.**

• If you miss a dose of NEW WOSULIN 30/70, inject it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not inject a double dose to make up for the missed one, as this can increase the risk of hypoglycemia (low blood sugar). Always monitor your blood sugar levels regularly and adjust your diet and activity accordingly. If you are unsure about what to do after missing a dose, consult your doctor or pharmacist for guidance.

• Keep NEW WOSULIN 30/70 PENFILL 3ML away from the reach of children and pets.
• Store NEW WOSULIN 30/70 PENFILL 3ML in a refrigerator (2 - 8°C). Do not freeze.

• **Understand Your Insulin:** NEW WOSULIN 30/70 is a premixed insulin, containing 30% rapid-acting and 70% intermediate-acting insulin. This combination helps manage blood sugar levels throughout the day. Ensure you understand how each component works to optimize its effectiveness. Always consult your doctor or diabetes educator for personalized guidance on its usage.
• **Proper Storage is Crucial:** Store your NEW WOSULIN 30/70 Penfill in the refrigerator (2°C to 8°C or 36°F to 46°F) until first use. Once in use, it can be stored at room temperature (below 30°C or 86°F) for up to 28 days, away from direct heat and sunlight. Never freeze it, and discard it if it has been frozen. Proper storage maintains its potency and ensures accurate dosing.
• **Administer Correctly:** Always use a new needle for each injection to prevent contamination and ensure comfort. Rotate injection sites (abdomen, thigh, or upper arm) to avoid lipodystrophy (fatty lumps under the skin). Clean the injection site with an alcohol swab before injecting. Follow your doctor's instructions precisely regarding dosage and timing of injections, typically 15-30 minutes before meals.
• **Monitor Blood Glucose Regularly:** Consistent blood glucose monitoring is essential to understand how NEW WOSULIN 30/70 is affecting your blood sugar levels. Keep a log of your readings and share it with your healthcare provider. This data helps in adjusting your insulin dosage, diet, and exercise regimen for optimal blood sugar control. Be aware of the signs and symptoms of both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar).
• **Diet and Exercise Matters:** NEW WOSULIN 30/70 works best when combined with a balanced diet and regular exercise. Work with a registered dietitian to create a meal plan that suits your needs and helps manage your blood sugar. Engage in regular physical activity, as advised by your doctor, to improve insulin sensitivity and overall health. Remember to check your blood sugar before, during, and after exercise, especially when starting a new workout routine.
• **Inspect the Penfill Before Use:** Before each use, visually inspect the NEW WOSULIN 30/70 Penfill. The insulin should appear uniformly cloudy or milky. Do not use it if it looks clear, contains particles, or has clumps, as this indicates it may be damaged or ineffective. Report any abnormalities to your pharmacist or healthcare provider.
• **Carry Identification and Emergency Supplies:** Always carry identification stating that you have diabetes and are using insulin. It's also wise to carry a glucagon kit and fast-acting carbohydrates (glucose tablets or juice) in case of hypoglycemia. Make sure your family, friends, and colleagues know how to recognize and treat low blood sugar.

• NEW WOSULIN 30/70 PENFILL 3 ML should be administered 15 minutes before or immediately after meals. Consistent timing with meals is crucial for managing blood sugar levels effectively.
• Avoid significant changes in your diet without consulting your doctor, as this can impact your insulin needs.
• Be mindful of the carbohydrate content of your meals, as insulin dosage is often adjusted based on carbohydrate intake. Consult with your healthcare provider or a registered dietitian for personalized dietary guidance.
• Alcohol consumption can affect blood sugar levels. If you consume alcohol, do so in moderation and monitor your blood sugar levels closely.