XMET TRIO 500/0.2/2MG TABLET 10'S
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XMET TRIO 500/0.2/2MG TABLET 10'S
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XMET TRIO 500/0.2/2MG TABLET 10'S

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XMET TRIO 500/0.2/2MG TABLET 10'S

By GLENMARK PHARMACEUTICALS LIMITED

MRP

164

₹139.4

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About XMET TRIO 500/0.2/2MG TABLET 10'S

  • XMET TRIO 500/0.2/2MG TABLET 10'S is a combination medicine used to treat type 2 diabetes mellitus. It is used in adults to improve blood sugar control along with diet and exercise. It contains a combination of three antidiabetic medicines: Metformin, Glimepiride and Voglibose.
  • Metformin works by decreasing glucose production in the liver and improving insulin sensitivity. Glimepiride stimulates the release of insulin from the pancreas. Voglibose inhibits the intestinal enzymes which break down complex sugars into glucose, thereby slowing down the absorption of glucose from the intestine into the blood. This combination helps to lower blood glucose levels in people with type 2 diabetes.
  • This medicine should be taken as prescribed by your doctor. The dosage and duration will depend on your individual needs and response to the medication. It is usually taken orally with meals to minimize gastrointestinal side effects. Common side effects may include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. It's important to monitor your blood sugar levels regularly while taking this medication.
  • XMET TRIO 500/0.2/2MG TABLET 10'S is a powerful tool in managing type 2 diabetes when combined with a healthy lifestyle. Consult your doctor for personalized advice and to ensure it's the right treatment option for you. Always inform your doctor about any other medications you are taking and any pre-existing medical conditions.

Uses of XMET TRIO 500/0.2/2MG TABLET 10'S

  • Treatment of Type 2 diabetes mellitus
  • Lowering high blood sugar levels
  • Improving insulin sensitivity
  • Controlling blood sugar levels after meals
  • Managing insulin resistance related to Polycystic Ovary Syndrome (PCOS) (off-label use)
  • Management of diabetes associated with obesity

How XMET TRIO 500/0.2/2MG TABLET 10'S Works

  • XMET TRIO 500/0.2/2MG Tablet is a combination medicine specifically designed to manage type 2 diabetes mellitus. It harmonizes the actions of three active ingredients: Metformin, Glimepiride, and Voglibose, each addressing a different facet of blood sugar control.
  • Metformin, a cornerstone in diabetes treatment, primarily reduces glucose production in the liver. It acts by suppressing hepatic gluconeogenesis, the process where the liver generates glucose from non-carbohydrate sources. Additionally, Metformin enhances insulin sensitivity in peripheral tissues like muscles, allowing them to utilize glucose more effectively. This dual action lowers both fasting and postprandial (after-meal) blood glucose levels. Furthermore, Metformin may offer benefits beyond glucose control, such as improving lipid profiles and potentially reducing cardiovascular risk.
  • Glimepiride belongs to the sulfonylurea class of drugs. It works by stimulating the beta cells in the pancreas to release more insulin. Insulin is the key hormone that unlocks cells, allowing glucose to enter and be used for energy. By increasing insulin secretion, Glimepiride helps lower blood glucose levels, particularly after meals. The effect of Glimepiride is dependent on the presence of functional beta cells in the pancreas, making it most effective in patients with some residual insulin production.
  • Voglibose is an alpha-glucosidase inhibitor. It functions by delaying the absorption of carbohydrates from the small intestine. Alpha-glucosidase enzymes are responsible for breaking down complex carbohydrates into simpler sugars that can be absorbed into the bloodstream. Voglibose inhibits these enzymes, slowing down the digestion and absorption of carbohydrates. This results in a blunted postprandial glucose rise, preventing sharp spikes in blood sugar levels after meals. Voglibose is particularly useful in controlling postprandial hyperglycemia.
  • In essence, XMET TRIO works synergistically to tackle multiple aspects of type 2 diabetes. Metformin reduces glucose production and improves insulin sensitivity, Glimepiride stimulates insulin release, and Voglibose delays carbohydrate absorption. This triple action helps to maintain stable blood glucose levels throughout the day, reducing the risk of both hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) when used as directed by a healthcare professional. It's crucial to use this medication in conjunction with lifestyle modifications like diet and exercise for optimal glycemic control.

Side Effects of XMET TRIO 500/0.2/2MG TABLET 10'SArrow

Possible side effects of XMET TRIO 500/0.2/2MG TABLET may include: * **Common:** Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, hypoglycemia (low blood sugar), headache, dizziness. * **Uncommon:** Skin rash, itching, allergic reactions, lactic acidosis (rare but serious), vitamin B12 deficiency (with long-term use), blurred vision, constipation, flatulence, weakness, fatigue. * **Rare:** Liver problems, abnormal blood counts. **Note:** This is not an exhaustive list. If you experience any unusual or severe symptoms while taking XMET TRIO, consult your doctor immediately.

Safety Advice for XMET TRIO 500/0.2/2MG TABLET 10'SArrow

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Allergies

Allergies

Allergies: Do not use XMET TRIO 500/0.2/2MG TABLET 10'S if you are allergic to it.

Dosage of XMET TRIO 500/0.2/2MG TABLET 10'SArrow

  • The recommended dosage of 'XMET TRIO 500/0.2/2MG TABLET 10'S' varies significantly depending on individual patient needs, pre-existing medical conditions, current medications, and the severity of the diabetes being treated. Your physician will determine the appropriate dosage based on a thorough evaluation of your health status. Typically, 'XMET TRIO 500/0.2/2MG TABLET 10'S' is initiated at a low dose to minimize gastrointestinal side effects and then gradually increased as needed to achieve optimal glycemic control. It is crucial to adhere strictly to the prescribed dosage and schedule. Do not alter the dosage or discontinue the medication without consulting your doctor.
  • The usual starting dose is often one tablet once or twice daily, taken with meals to help reduce stomach upset. The maximum daily dose should not exceed the amount specified by your healthcare provider. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. Regular monitoring of blood glucose levels is essential while taking 'XMET TRIO 500/0.2/2MG TABLET 10'S' to assess its effectiveness and adjust the dosage accordingly.
  • Factors that may influence the dosage include your blood sugar levels, kidney function, liver function, and response to treatment. Elderly patients may require lower doses due to age-related changes in kidney and liver function. Your doctor may also adjust the dosage if you are taking other medications that can interact with 'XMET TRIO 500/0.2/2MG TABLET 10'S'. It is important to inform your doctor about all the medications, supplements, and herbal products you are currently taking. Periodic blood tests and check-ups are necessary to monitor your health and adjust the dosage as needed to ensure the best possible outcome. Take 'XMET TRIO 500/0.2/2MG TABLET 10'S' only as per the prescription by your physician only.

What if I miss my dose of XMET TRIO 500/0.2/2MG TABLET 10'S?Arrow

  • If you miss a dose of XMET TRIO 500/0.2/2MG TABLET 10'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How to store XMET TRIO 500/0.2/2MG TABLET 10'S?Arrow

  • Keep XMET TRIO 500/0.2/2MG TAB 1X10 away from the reach of children and pets.
  • Store XMET TRIO 500/0.2/2MG TAB 1X10 at room temperature.

Benefits of XMET TRIO 500/0.2/2MG TABLET 10'SArrow

  • XMET TRIO 500/0.2/2MG TABLET 10'S is a comprehensive oral antidiabetic medication combining three active ingredients – Metformin, Glimepiride, and Voglibose – to provide multifaceted benefits in managing type 2 diabetes mellitus. This triple combination therapy is designed to address various underlying mechanisms contributing to elevated blood sugar levels, offering a synergistic approach to glycemic control.
  • One of the primary benefits of XMET TRIO is its ability to effectively lower blood glucose levels. Metformin, a biguanide, reduces hepatic glucose production and enhances insulin sensitivity in peripheral tissues, allowing cells to utilize glucose more efficiently. Glimepiride, a sulfonylurea, stimulates insulin release from the pancreas, further aiding in glucose utilization. Voglibose, an alpha-glucosidase inhibitor, slows down the absorption of carbohydrates from the small intestine, preventing rapid postprandial glucose spikes.
  • By targeting different pathways of glucose metabolism, XMET TRIO provides superior glycemic control compared to monotherapy or dual therapy. It helps in achieving and maintaining optimal HbA1c levels, a key indicator of long-term blood sugar management. This comprehensive approach reduces the risk of diabetes-related complications, such as cardiovascular diseases, nerve damage (neuropathy), kidney damage (nephropathy), and eye damage (retinopathy).
  • XMET TRIO offers the convenience of a single tablet formulation, simplifying medication regimens and improving patient compliance. This is particularly beneficial for individuals managing multiple medications. The combination of three drugs in one tablet ensures that patients receive a consistent dose of each medication, optimizing therapeutic outcomes and minimizing the potential for missed doses.
  • Furthermore, XMET TRIO can contribute to weight management. Metformin, in particular, has been associated with modest weight loss or weight stabilization, which is an added advantage for overweight or obese individuals with type 2 diabetes. Maintaining a healthy weight is crucial for overall metabolic health and can further improve insulin sensitivity.
  • The use of XMET TRIO can also lead to an improvement in lipid profiles. Metformin has been shown to have beneficial effects on cholesterol and triglyceride levels, reducing the risk of cardiovascular events in diabetic patients. Effective glucose control achieved with XMET TRIO can indirectly contribute to better lipid management.
  • In summary, XMET TRIO 500/0.2/2MG TABLET 10'S offers a powerful and convenient solution for managing type 2 diabetes. Its triple-action mechanism provides comprehensive glycemic control, reduces the risk of complications, improves patient compliance, aids in weight management, and promotes better lipid profiles, ultimately enhancing the overall health and quality of life for individuals with diabetes.

How to use XMET TRIO 500/0.2/2MG TABLET 10'SArrow

  • XMET TRIO 500/0.2/2MG TABLET 10'S is an oral medication and should be taken exactly as prescribed by your doctor. The usual dosage is one tablet, once or twice daily, but this may vary depending on your individual needs and response to the treatment. Always follow your doctor's instructions carefully. It is recommended to take this medicine with food to minimize the risk of stomach upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
  • Consistency is key for optimal results. Try to take XMET TRIO 500/0.2/2MG TABLET 10'S at the same time(s) each day to help you remember. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for a missed one.
  • Regular monitoring of your blood sugar levels is crucial while taking XMET TRIO 500/0.2/2MG TABLET 10'S. Your doctor may also recommend periodic blood tests to monitor your kidney function and vitamin B12 levels, as metformin, one of the ingredients in this medication, can affect these. It is important to inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements, as they may interact with XMET TRIO. Also, discuss any existing medical conditions, especially kidney or liver problems, before starting this medication.
  • Lifestyle modifications, such as diet and exercise, are essential for managing your condition effectively. Follow a balanced diet plan recommended by your doctor or a registered dietitian and engage in regular physical activity. These lifestyle changes, along with XMET TRIO 500/0.2/2MG TABLET 10'S, will help you achieve better blood sugar control. If you experience any unusual side effects, such as nausea, vomiting, diarrhea, or abdominal pain, consult your doctor immediately. It is also important to stay hydrated by drinking plenty of water throughout the day.

Quick Tips for XMET TRIO 500/0.2/2MG TABLET 10'SArrow

  • **Take XMET TRIO 500/0.2/2MG Tablet as prescribed:** Always adhere to your doctor's dosage instructions and timing. Consistency is key to managing your blood sugar effectively. Do not alter the dosage without consulting your healthcare provider.
  • **Monitor your blood sugar regularly:** Keep a close watch on your blood glucose levels using a home glucose monitor. Regular monitoring helps you and your doctor understand how the medication and your lifestyle are impacting your diabetes management. Share these readings with your doctor during your checkups.
  • **Follow a balanced diet:** Complement your medication with a healthy diet. Focus on incorporating whole grains, fruits, vegetables, and lean proteins. Limit your intake of sugary foods, processed snacks, and excessive carbohydrates to help stabilize blood sugar levels.
  • **Stay physically active:** Engage in regular physical activity, such as brisk walking, jogging, swimming, or cycling. Aim for at least 30 minutes of moderate-intensity exercise most days of the week. Exercise improves insulin sensitivity and helps manage your weight, both crucial for diabetes control.
  • **Be aware of potential side effects:** XMET TRIO can cause side effects such as nausea, diarrhea, or low blood sugar (hypoglycemia). If you experience any unusual symptoms, especially severe ones, consult your doctor immediately. Carry a source of fast-acting glucose, like glucose tablets or juice, in case of hypoglycemia.

Food Interactions with XMET TRIO 500/0.2/2MG TABLET 10'SArrow

  • XMET TRIO 500/0.2/2MG TABLET 10'S should be taken with food to minimize gastrointestinal side effects. Consistent timing with meals is recommended.
  • Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of lactic acidosis and hypoglycemia.

FAQs

What is XMET TRIO 500/0.2/2MG TABLET and what is it used for?Arrow

XMET TRIO 500/0.2/2MG TABLET is a combination medicine used to treat type 2 diabetes mellitus when diet and exercise alone are not enough to control blood sugar levels.

What are the active ingredients in XMET TRIO 500/0.2/2MG TABLET?Arrow

XMET TRIO 500/0.2/2MG TABLET contains Metformin, Glimepiride and Voglibose as active ingredients.

What are the common side effects of XMET TRIO 500/0.2/2MG TABLET?Arrow

Common side effects of XMET TRIO 500/0.2/2MG TABLET include nausea, vomiting, diarrhea, abdominal pain, and headache.

Should XMET TRIO 500/0.2/2MG TABLET be taken on an empty stomach?Arrow

It is recommended to take XMET TRIO 500/0.2/2MG TABLET with or immediately after food.

How should XMET TRIO 500/0.2/2MG TABLET be stored?Arrow

Store XMET TRIO 500/0.2/2MG TABLET at room temperature, away from moisture and light.

Is XMET TRIO 500/0.2/2MG TABLET safe during pregnancy?Arrow

The safety of XMET TRIO 500/0.2/2MG TABLET during pregnancy is not established. It should only be used if clearly needed and advised by a doctor.

Is XMET TRIO 500/0.2/2MG TABLET safe for breastfeeding women?Arrow

It is not known whether XMET TRIO 500/0.2/2MG TABLET is excreted in breast milk. It is important to consult a doctor before using it during breastfeeding.

What to do in case of an overdose of XMET TRIO 500/0.2/2MG TABLET?Arrow

In case of an overdose of XMET TRIO 500/0.2/2MG TABLET, seek immediate medical attention.

Can XMET TRIO 500/0.2/2MG TABLET interact with other medications?Arrow

XMET TRIO 500/0.2/2MG TABLET can interact with other medications. Inform your doctor about all the medicines you are taking.

What foods should be avoided while taking XMET TRIO 500/0.2/2MG TABLET?Arrow

It is advisable to avoid high sugar foods and beverages while taking XMET TRIO 500/0.2/2MG TABLET.

Is XMET TRIO 500/0.2/2MG TABLET safe for patients with kidney disease?Arrow

XMET TRIO 500/0.2/2MG TABLET should be used with caution in patients with kidney disease. The dosage may need to be adjusted by the doctor.

Is XMET TRIO 500/0.2/2MG TABLET safe for patients with heart disease?Arrow

XMET TRIO 500/0.2/2MG TABLET should be used with caution in patients with heart disease. Consult a doctor.

What happens if I miss a dose of XMET TRIO 500/0.2/2MG TABLET?Arrow

If you miss a dose of XMET TRIO 500/0.2/2MG TABLET, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular schedule.

How long does it take for XMET TRIO 500/0.2/2MG TABLET to work?Arrow

The time it takes for XMET TRIO 500/0.2/2MG TABLET to work can vary from person to person. Improvement in blood sugar levels is usually seen within a few weeks.

Can I drink alcohol while taking XMET TRIO 500/0.2/2MG TABLET?Arrow

Alcohol should be avoided while taking XMET TRIO 500/0.2/2MG TABLET, as it can increase the risk of low blood sugar levels.

References

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DrugBank: Metformin. This entry provides detailed chemical, pharmacological, and clinical information about metformin, one of the active ingredients often found in combination diabetes medications. It may provide information relevant to XMET TRIO if it contains metformin.

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DrugBank: Glimepiride. Detailed information on Glimepiride including its mechanism of action, pharmacology, and clinical usage. Glimepiride is another common anti-diabetic medication that could be present in XMET TRIO.

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FDA Orange Book. This is a good source for looking up approved drug products with therapeutic equivalence evaluations. It can help confirm the approved uses and manufacturers of drugs containing Metformin and Glimepiride.

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PubMed Central (PMC). A free archive of biomedical and life sciences literature. Searching for 'Metformin Glimepiride combination' or specific details about the dosages in XMET TRIO (500/0.2/2MG) may yield relevant research articles.

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European Medicines Agency (EMA). The official website of the European Medicines Agency. Search the EMA site for documents related to metformin and glimepiride combinations. This might provide regulatory and scientific insights.

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