DAPARYL L 10/5MG TABLET 15'S

How DAPARYL L 10/5MG TABLET 15'S Works

• DAPARYL L 10/5MG TABLET 15'S is a combination medication containing Dapagliflozin and Linagliptin, designed to manage blood sugar levels in adults with type 2 diabetes. To understand how it works, it's essential to break down the actions of each component.
• Dapagliflozin belongs to a class of drugs called Sodium-Glucose Co-Transporter 2 (SGLT2) inhibitors. The kidneys filter glucose from the blood, and SGLT2 is responsible for reabsorbing glucose back into the bloodstream. Dapagliflozin inhibits SGLT2, preventing the kidneys from reabsorbing glucose. As a result, excess glucose is excreted through urine, effectively lowering blood sugar levels. This mechanism is independent of insulin, making it beneficial even when insulin production or sensitivity is impaired. In addition to lowering blood sugar, Dapagliflozin can also lead to modest weight loss and blood pressure reduction.
• Linagliptin, on the other hand, is a Dipeptidyl Peptidase-4 (DPP-4) inhibitor. DPP-4 is an enzyme that breaks down incretin hormones, such as GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-dependent Insulinotropic Polypeptide). These incretin hormones play a crucial role in regulating blood sugar by stimulating insulin release from the pancreas and suppressing glucagon secretion from the liver, both of which occur in a glucose-dependent manner. By inhibiting DPP-4, Linagliptin increases the levels of active incretin hormones in the body. This leads to enhanced insulin secretion when blood sugar is high and reduced glucagon secretion, helping to lower blood sugar levels. Linagliptin's action is also glucose-dependent, meaning it primarily works when blood sugar is elevated, reducing the risk of hypoglycemia (low blood sugar).
• In summary, DAPARYL L 10/5MG TABLET 15'S works through a dual mechanism: Dapagliflozin promotes glucose excretion via the kidneys, while Linagliptin enhances the body's own ability to regulate blood sugar through incretin hormones. The combination of these two drugs provides a more comprehensive approach to managing type 2 diabetes, addressing different aspects of the disease and helping patients achieve better glycemic control. This synergistic effect often results in improved HbA1c levels, reduced fasting and postprandial blood sugar, and a decreased risk of diabetes-related complications. Always take this medication as prescribed by your healthcare provider, and combine it with lifestyle modifications such as diet and exercise for optimal results.

Common side effects of DAPARYL L 10/5MG TABLET may include: Headache, Dizziness, Fatigue, Sleepiness, Nausea, Vomiting, Stomach pain, Diarrhea, Constipation, Cough, Flu-like symptoms, Increased heart rate (palpitations), Low blood pressure (hypotension), Swelling of ankles or feet (edema). Uncommon side effects may include: Muscle cramps or weakness, Back pain, Joint pain, Blurred vision, Dry mouth, Increased sweating, Skin rash or itching, Hair loss, Mood changes (anxiety, depression), Difficulty sleeping (insomnia), Sexual dysfunction, Allergic reactions (hives, swelling of face/throat, difficulty breathing). Rare but serious side effects may include: Liver problems (yellowing of skin/eyes), Kidney problems (changes in urination), Severe allergic reactions (anaphylaxis), Heart attack, Stroke.

• If you miss a dose of DAPARYL L 10/5MG TABLET 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

• Keep DAPARYL L 10/5MG TAB 1X10 away from the reach of children and pets.
• Store DAPARYL L 10/5MG TAB 1X10 at room temperature.

• **Take as Directed:** Always take DAPARYL L 10/5MG TABLET 15'S exactly as prescribed by your doctor. Do not change the dosage or stop taking the medication without consulting your healthcare provider. Consistency is key for optimal blood pressure and cholesterol control. Setting a daily alarm can help you remember to take your dose at the same time each day.
• **Dietary Considerations:** While taking DAPARYL L 10/5MG TABLET 15'S, maintain a heart-healthy diet. Reduce your intake of saturated and trans fats, cholesterol, and sodium. Increase your consumption of fruits, vegetables, and whole grains. A balanced diet complements the medication's effects in managing your cardiovascular health. Consider consulting a nutritionist for personalized dietary advice.
• **Monitor Blood Pressure Regularly:** Keep a regular check on your blood pressure levels. Record your readings and share them with your doctor during follow-up appointments. This helps in assessing the effectiveness of DAPARYL L 10/5MG TABLET 15'S and making any necessary adjustments to your treatment plan. Home blood pressure monitors are readily available and easy to use.
• **Lifestyle Modifications:** Incorporate lifestyle changes such as regular exercise (at least 30 minutes of moderate-intensity activity most days of the week), weight management, and stress reduction techniques. These modifications can significantly improve your overall cardiovascular health and enhance the benefits of DAPARYL L 10/5MG TABLET 15'S. Activities like brisk walking, cycling, or swimming are excellent choices.
• **Be Aware of Potential Side Effects:** Be aware of potential side effects such as dizziness, headache, or muscle pain. If you experience any persistent or bothersome side effects, inform your doctor promptly. Do not ignore any unusual symptoms. Your doctor can provide guidance on managing side effects or adjust your medication if necessary. Never self-medicate to treat side effects.
• **Avoid Grapefruit and Grapefruit Juice:** While on DAPARYL L 10/5MG TABLET 15'S, avoid consuming grapefruit or grapefruit juice. Grapefruit can interfere with the metabolism of certain medications, potentially increasing the risk of side effects. This interaction can affect how the medication works in your body.
• **Limit Alcohol Consumption:** Limit your alcohol intake while taking DAPARYL L 10/5MG TABLET 15'S. Excessive alcohol consumption can raise blood pressure and interfere with the medication's effectiveness. It can also increase the risk of certain side effects. Consult your doctor about safe alcohol consumption levels while on this medication.

• DAPARYL L 10/5MG TABLET 15'S can be taken with or without food. However, it is important to take the medicine at the same time each day to maintain consistent blood levels. Avoid consuming large amounts of grapefruit or grapefruit juice while taking this medication, as it may increase the level of the drug in your blood.