DENBRI INJECTION
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DENBRI INJECTION
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DENBRI INJECTION

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DENBRI INJECTION

By RPG LIFE SCIENCES LIMITED

MRP

23500

₹13697

41.71 % OFF

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Composition

Product DetailsArrow

About DENBRI INJECTION

  • DENBRI INJECTION contains the active ingredient Denosumab and is prescribed for managing osteoporosis, a condition characterized by weakened and brittle bones, making them more susceptible to fractures. It is also used to prevent skeletal-related events in individuals with specific cancers, including multiple myeloma and bone metastases from solid tumors. DENBRI INJECTION functions by targeting and inhibiting RANKL (receptor activator of nuclear factor kappa-B ligand), a protein that regulates the formation, function, and survival of osteoclasts, which are cells responsible for bone resorption (breakdown). By inhibiting RANKL, DENBRI INJECTION reduces bone resorption, leading to increased bone mineral density (BMD) and reduced risk of fractures.
  • Clinical studies have demonstrated that DENBRI INJECTION significantly increases BMD in various skeletal sites, such as the spine and hip, resulting in a substantial reduction in the risk of vertebral and non-vertebral fractures in postmenopausal women with osteoporosis. Similarly, it has shown efficacy in preventing or delaying bone complications, such as fractures, spinal cord compression, or the need for radiation or surgery to the bone, in patients with cancer that has spread to the bone. For individuals with pre-existing moderate renal impairment, close monitoring of kidney function may be warranted throughout the course of treatment with DENBRI INJECTION.
  • DENBRI INJECTION is contraindicated in individuals with known hypersensitivity or allergic reactions to Denosumab or any of the excipients in the formulation. During treatment with DENBRI INJECTION, it is crucial to maintain adequate calcium and vitamin D levels through supplementation, as Denosumab can lower blood calcium levels. This medication is not indicated for use in children and adolescents under the age of 18, as its safety and efficacy have not been thoroughly evaluated in pediatric populations. Caution should be exercised when administering DENBRI INJECTION to individuals with pre-existing hypoparathyroidism, a condition characterized by abnormally low levels of parathyroid hormone, which plays a vital role in calcium regulation. Management by a healthcare professional is essential in such cases.

Uses of DENBRI INJECTION

  • DENBRI INJECTION is used in the treatment of the following condition: Osteoporosis (weakening of the bones).
  • Bone loss due to hormonal therapy in breast or prostate cancer.
  • Multiple myeloma (a cancer that affects plasma cells in the bone marrow).
  • Bone metastases (cancer that spreads to bone).

Side Effects of DENBRI INJECTIONArrow

Like all medications, DENBRI INJECTION can cause side effects, although not everyone who takes it will experience them. Serious side effects include osteonecrosis of the jaw (severe necrosis or death of jaw cells), atypical femoral fractures, and hypocalcemia (low blood calcium levels). Common side effects include injection site reactions, back pain, musculoskeletal pain, infections, abdominal pain, headache, and hypophosphatemia (low blood phosphate levels).

  • Osteonecrosis of the jaw (severe necrosis or death of jaw cells)
  • Atypical femoral fractures
  • Hypocalcemia (low blood calcium levels)
  • Injection site reactions
  • Back pain
  • Musculoskeletal pain
  • Infections
  • Abdominal pain
  • Headache
  • Hypophosphatemia (low blood phosphate levels)

Safety Advice for DENBRI INJECTIONArrow

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Pregnancy

CONSULT YOUR DOCTOR

The safety of using DENBRI INJECTION during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.

Dosage of DENBRI INJECTIONArrow

  • DENBRI INJECTION is administered directly by qualified healthcare professionals to ensure accurate and safe delivery. It is crucial to adhere to the prescribed dosage and treatment schedule as determined by your healthcare provider. The specific dosage will depend on various factors, including the patient's medical condition, the severity of the condition being treated, and the individual's response to the medication.
  • The duration of treatment with DENBRI INJECTION will also be determined by your healthcare provider based on your individual needs and progress. It's important to complete the full course of treatment as prescribed, even if you start to feel better before the treatment is finished. Any adjustments to the dosage or treatment schedule should only be made under the guidance of a healthcare professional.
  • Self-administration of DENBRI INJECTION is not recommended. The injection should only be given by trained medical personnel in a clinical setting where appropriate monitoring and support are available. This helps to minimize the risk of potential side effects and ensure optimal therapeutic outcomes.

How to store DENBRI INJECTION?Arrow

  • Keep DENBRI 60MG INJ 1ML away from the reach of children and pets.
  • Store DENBRI 60MG INJ 1ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of DENBRI INJECTIONArrow

  • DENBRI INJECTION offers a range of therapeutic benefits, primarily focused on improving bone health and reducing the risk of fractures. It works by inhibiting bone resorption, a process where old bone tissue is broken down and removed, through its targeted action on RANK ligands. By slowing down this process, DENBRI INJECTION allows for greater bone density and strength, directly addressing the underlying causes of osteoporosis and related conditions.
  • The medication's key effects include a significant reduction in fracture risk, particularly in individuals diagnosed with osteoporosis or those identified as being at high risk of developing the condition. By promoting stronger bones, DENBRI INJECTION minimizes the likelihood of fractures resulting from falls or minor impacts. Moreover, it demonstrably increases bone mineral density (BMD), a crucial indicator of bone strength and overall skeletal health. Higher BMD scores correlate with a reduced risk of fractures and improved long-term bone health.
  • In essence, DENBRI INJECTION plays a vital role in fortifying bones, decreasing fracture susceptibility, and fostering enhanced bone well-being. These therapeutic advantages contribute to a better quality of life for patients, allowing them to maintain mobility, independence, and overall physical function.

How to use DENBRI INJECTIONArrow

  • DENBRI INJECTION is administered by qualified healthcare professionals via injection. It is crucial to understand that this medication is not intended for self-administration. The precise dosage, frequency, and duration of treatment will be determined by your healthcare provider, taking into account your specific medical condition, its severity, and your individual response to the medication. Your doctor will carefully evaluate these factors to establish the most effective treatment plan for you.
  • It is important to adhere to the schedule and dosage prescribed by your doctor. Do not attempt to adjust the dosage or discontinue treatment without first consulting with your healthcare provider. Doing so could potentially impact the effectiveness of the medication and your overall treatment outcome.
  • If you have any concerns or questions regarding DENBRI INJECTION or its administration, please do not hesitate to discuss them with your doctor or other healthcare professional. They are the best resource for providing you with accurate and personalized information about your treatment.

FAQs

Can DENBRI INJECTION be used in patients with a history of cancer?Arrow

DENBRI INJECTION is not recommended in patients with a history of certain cancers, such as multiple myeloma or bone metastases. It is important to discuss your medical history and any previous or current cancer diagnoses with your healthcare provider before starting this medication.

Can DENBRI INJECTION be used in patients with kidney problems?Arrow

DENBRI INJECTION is primarily eliminated through the kidneys, so caution is advised in patients with severe renal impairment or end-stage renal disease. Your healthcare provider will assess the potential risks and benefits based on your renal function.

Can DENBRI INJECTION be used as a treatment for osteoporosis in men?Arrow

Yes, DENBRI INJECTION is approved for the treatment of osteoporosis in men at increased risk of fractures. It can help improve bone density and reduce fracture risk in male patients with osteoporosis.

Can DENBRI INJECTION be used in children and adolescents with osteoporosis?Arrow

DENBRI INJECTION is not approved for use in children and adolescents with osteoporosis. The safety and efficacy of this medication have not been established in this population.

Can DENBRI INJECTION be used in individuals with dental implants?Arrow

DENBRI INJECTION use has been associated with a slightly increased risk of jaw osteonecrosis (ONJ). Suppose you have dental implants or are considering getting them. In that case, it is important to discuss this with your dentist and healthcare provider to assess DENBRI INJECTION's potential risks and benefits.

What Are the Side Effects of DENBRI INJECTION?Arrow

DENBRI INJECTION can cause side effects like injection site reactions, back and musculoskeletal pain, infections, abdominal pain, headache, and low blood phosphate levels. Rare but serious side effects may include osteonecrosis of the jaw, atypical femoral fractures, hypocalcemia, and severe skin reactions.

Are there any known interactions of DENBRI INJECTION with other drugs?Arrow

NULL interaction of DENBRI INJECTION with other drungs

What advice is related to DENBRI INJECTION?Arrow

Attend all scheduled appointments and follow-up visits to monitor your response to treatment and address any concerns or side effects. Tell your doctor about your medical history, previous infection, liver disease, and kidney disease. Inform your healthcare provider about any allergies or hypersensitivity reactions you may have. Seek immediate medical attention if you experience severe allergic reactions or other serious side effects. Additionally, DENBRI INJECTION may affect calcium levels, so monitoring calcium levels and ensuring adequate calcium and vitamin D intake is important. Pregnant and breastfeeding women should consult a doctor before taking this medication. Avoid taking any vaccines during treatment. Regular dental examinations and good oral hygiene practices are recommended to minimize the risk of jaw osteonecrosis.

Which molecule/combination is used for making DENBRI INJECTION?Arrow

DENOSUMAB is molecule/combination used for making DENBRI INJECTION.

For which ailments/diseases/conditions is DENBRI INJECTION prescribed?Arrow

DENBRI INJECTION is presecribed for Rheumatology,Orthopaedics,Gastroenterology ailments/disease/conditions.

References

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Amgen Ltd, Electronic medicines compendium (EMC)

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Amgen Manufacturing Limited, US Food and Drug Administration

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Amgen Manufacturing Limited, US Food and Drug Administration

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Excellent service and support 24/7 Supportive and co operative staff.

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Reviewed on 13-01-2024

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Very good place for medicine allmost all the medicine are available at discounted rate.

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Reviewed on 10-03-2024

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(5/5)

Medicines available at good discounted rates and it really help the pockets of the customer...even they help in getting medicines when you order and give your number ..

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Reviewed on 03-02-2024

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Good pharmacy

shashiprakash sharma

Reviewed on 20-08-2023

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(5/5)

Nice service All required drugs are available 😊

Meet Dobariya

Reviewed on 13-01-2024

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(5/5)


Marketer / Manufacturer Details

RPG LIFE SCIENCES LIMITED

Country of Origin -

India

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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