DENINTA 60MG INJECTION
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DENINTA 60MG INJECTION
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DENINTA 60MG INJECTION

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DENINTA 60MG INJECTION

By INTAS PHARMACEUTICALS LIMITED

MRP

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20000

₹13500

32.5 % OFF

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Composition

DENOSUMAB 60 MG

Product DetailsArrow

About DENINTA 60MG INJECTION

  • DENINTA 60MG INJECTION contains the active ingredient Denosumab. It's a medication primarily used in the treatment of osteoporosis, a condition characterized by weakened and brittle bones, making them more susceptible to fractures. Beyond osteoporosis, it is also prescribed to prevent skeletal-related complications in individuals with certain cancers, including multiple myeloma and bone metastases from solid tumors. This proactive approach helps to maintain bone integrity and reduce the risk of fractures or other bone-related issues associated with cancer.
  • DENINTA 60MG INJECTION functions by targeting and inhibiting a protein known as RANK ligand (RANKL). RANKL is a key regulator of osteoclasts, the cells responsible for breaking down bone tissue. By blocking RANKL, the medication effectively slows down bone resorption, allowing bone density to increase over time. Clinical studies have demonstrated its effectiveness in significantly increasing bone mineral density (BMD), thereby reducing the risk of fractures, particularly in postmenopausal women diagnosed with osteoporosis, as well as in patients experiencing bone loss due to cancer treatments or the disease itself. Patients with moderate renal impairment may require close monitoring of their kidney function during the treatment period.
  • DENINTA 60MG INJECTION is contraindicated in individuals with a known hypersensitivity or allergic reaction to Denosumab or any of the other components of the formulation. Prior to commencing treatment, it's crucial to ensure that patients have adequate calcium and vitamin D levels, and supplementation is often recommended throughout the duration of therapy to support bone health. This medication is not indicated for use in children and adolescents under the age of 18 years, as its safety and efficacy have not been thoroughly evaluated in these populations. Caution is advised when administering DENINTA 60MG INJECTION to individuals with pre-existing hypoparathyroidism, a condition characterized by abnormally low levels of parathyroid hormone, as it may exacerbate the condition. Monitoring calcium levels is also important in these patients.

Uses of DENINTA 60MG INJECTION

  • DENINTA 60MG INJECTION is used in the treatment of the following condition: Osteoporosis (weakening of the bone).
  • Bone loss due to hormonal therapy in breast or prostate cancer.
  • Multiple myeloma (a cancer that affects plasma cells in the bone marrow).
  • Bone metastases (cancer that spreads to bone).

Side Effects of DENINTA 60MG INJECTIONArrow

Like all medications, DENINTA 60MG INJECTION can cause side effects, although not everyone experiences them. Serious side effects include osteonecrosis of the jaw (severe necrosis or death of jaw cells), atypical femoral fractures, and hypocalcemia (low blood calcium levels). Common side effects include injection site reactions, back pain, musculoskeletal pain, infections, abdominal pain, headache, and hypophosphatemia (low blood phosphate levels).

  • Osteonecrosis of the jaw (severe necrosis or death of jaw cells)
  • Atypical femoral fractures
  • Hypocalcemia (low blood calcium levels)
  • Injection site reactions
  • Back pain
  • Musculoskeletal pain
  • Infections
  • Abdominal pain
  • Headache
  • Hypophosphatemia (low blood phosphate levels)

Safety Advice for DENINTA 60MG INJECTIONArrow

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Pregnancy

CONSULT YOUR DOCTOR

The safety of using DENINTA 60MG INJECTION during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.

Dosage of DENINTA 60MG INJECTIONArrow

  • DENINTA 60MG INJECTION is administered via injection by qualified healthcare professionals only. It is crucial to understand that self-administration is strictly prohibited due to the potential risks and the need for precise monitoring.
  • The specific dosage and the length of the treatment period are determined by a healthcare provider, taking into account your unique medical condition, its severity, and your body's response to the medication. Regular monitoring and assessment are essential to adjust the treatment plan effectively.
  • Your healthcare provider will carefully evaluate several factors before deciding on the appropriate dosage, including your overall health, any existing medical conditions, and other medications you might be taking. This comprehensive evaluation ensures the safest and most effective treatment strategy.
  • It is vital to adhere strictly to the dosage and schedule prescribed by your healthcare provider. Any deviations from the recommended regimen could compromise the effectiveness of the treatment and potentially lead to adverse effects. Always consult with your doctor or pharmacist if you have any questions or concerns regarding your treatment plan.

How to store DENINTA 60MG INJECTION?Arrow

  • Keep DENINTA 60MG INJ 1ML away from the reach of children and pets.
  • Store DENINTA 60MG INJ 1ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of DENINTA 60MG INJECTIONArrow

  • DENINTA 60MG INJECTION offers significant therapeutic benefits, primarily focused on enhancing bone health and reducing fracture risk. This medication is particularly effective for individuals suffering from osteoporosis or those identified as being at high risk of fractures.
  • By targeting RANK ligands, DENINTA 60MG INJECTION effectively inhibits bone resorption, the process where old bone tissue is broken down and removed. Slowing down this process allows new bone formation to keep pace, resulting in stronger, denser bones.
  • A key therapeutic effect of DENINTA 60MG INJECTION is its ability to increase bone mineral density (BMD). BMD is a crucial indicator of bone strength; higher BMD values correlate with a lower risk of fractures. Regular use of this injection can lead to a measurable improvement in BMD, offering a tangible benefit to patients.
  • The combined effect of reduced bone resorption and increased bone mineral density translates to a significant reduction in the likelihood of fractures, especially in the spine, hip, and wrist – common sites affected by osteoporosis. This not only improves physical well-being but also contributes to a better overall quality of life by enhancing mobility and independence.
  • Furthermore, DENINTA 60MG INJECTION plays a role in improving overall bone health. Stronger bones provide better support for the body, reducing pain and discomfort associated with weakened bones. This medication empowers patients to maintain an active lifestyle and participate in daily activities with greater confidence and ease.

How to use DENINTA 60MG INJECTIONArrow

  • DENINTA 60MG INJECTION is administered by qualified healthcare professionals via injection, ensuring precise dosage and administration. It is crucial to understand that the specific dosage regimen and the duration of treatment will be tailored to each patient's unique medical condition and their individual response to the medication.
  • Therefore, the administration schedule and dosage must be determined exclusively by a healthcare provider who possesses a comprehensive understanding of the patient's health profile. Self-administration is strictly discouraged due to the potential for complications and the necessity for professional monitoring.
  • Healthcare providers will consider various factors, including the severity of the condition being treated, the patient's weight, kidney function, and other medications the patient may be taking, before determining the appropriate dosage. Regular monitoring during treatment is essential to assess the effectiveness of the injection and to identify any potential side effects.
  • Patients should openly communicate with their healthcare providers about any concerns or changes in their health status during the course of treatment with DENINTA 60MG INJECTION. This collaborative approach ensures optimal therapeutic outcomes and patient safety.

FAQs

<strong>Can DENINTA 60MG INJECTION be used in patients with a history of cancer?</strong>Arrow

DENINTA 60MG INJECTION is not recommended in patients with a history of certain cancers, such as multiple myeloma or bone metastases. It is important to discuss your medical history and any previous or current cancer diagnoses with your healthcare provider before starting this medication.

<strong>Can DENINTA 60MG INJECTION be used in patients with kidney problems?</strong>Arrow

DENINTA 60MG INJECTION is primarily eliminated through the kidneys, so caution is advised in patients with severe renal impairment or end-stage renal disease. Your healthcare provider will assess the potential risks and benefits based on your renal function.

<strong>Can DENINTA 60MG INJECTION be used as a treatment for osteoporosis in men?</strong>Arrow

Yes, DENINTA 60MG INJECTION is approved for the treatment of osteoporosis in men at increased risk of fractures. It can help improve bone density and reduce fracture risk in male patients with osteoporosis.

<strong>Can DENINTA 60MG INJECTION be used in children and adolescents with osteoporosis?</strong>Arrow

DENINTA 60MG INJECTION is not approved for use in children and adolescents with osteoporosis. The safety and efficacy of this medication have not been established in this population.

<strong>Can DENINTA 60MG INJECTION be used in individuals with dental implants?</strong>Arrow

DENINTA 60MG INJECTION use has been associated with a slightly increased risk of jaw osteonecrosis (ONJ). Suppose you have dental implants or are considering getting them. In that case, it is important to discuss this with your dentist and healthcare provider to assess DENINTA 60MG INJECTION's potential risks and benefits.

<strong>What Are the Side Effects of DENINTA 60MG INJECTION?</strong>Arrow

DENINTA 60MG INJECTION can cause side effects like injection site reactions, back and musculoskeletal pain, infections, abdominal pain, headache, and low blood phosphate levels. Rare but serious side effects may include osteonecrosis of the jaw, atypical femoral fractures, hypocalcemia, and severe skin reactions.

What are the drug interactions of DENINTA 60MG INJECTION?Arrow

There are no known significant negative interactions of DENINTA 60MG INJECTION with other drugs.

What advice should I follow while taking DENINTA 60MG INJECTION?Arrow

Attend all scheduled appointments and follow-up visits to monitor your response to treatment and address any concerns or side effects. Tell your doctor about your medical history, previous infection, liver disease, and kidney disease. Inform your healthcare provider about any allergies or hypersensitivity reactions you may have. Seek immediate medical attention if you experience severe allergic reactions or other serious side effects. Additionally, DENINTA 60MG INJECTION may affect calcium levels, so monitoring calcium levels and ensuring adequate calcium and vitamin D intake is important. Pregnant and breastfeeding women should consult a doctor before taking this medication. Avoid taking any vaccines during treatment. Regular dental examinations and good oral hygiene practices are recommended to minimize the risk of jaw osteonecrosis.

What molecule/combination is used for making DENINTA 60MG INJECTION?Arrow

DENOSUMAB is molecule/combination used for making DENINTA 60MG INJECTION.

For what ailments/diseases/conditions is DENINTA 60MG INJECTION prescribed?Arrow

DENINTA 60MG INJECTION is prescribed for ailments/diseases/conditions related to Rheumatology and Orthopaedics.

References

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Amgen Ltd, Electronic medicines compendium (EMC)

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Amgen Manufacturing Limited, US Food and Drug Administration

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Amgen Manufacturing Limited, US Food and Drug Administration

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Marketer / Manufacturer Details

INTAS PHARMACEUTICALS LIMITED

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