DENUB 60MG INJECTION
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DENUB 60MG INJECTION
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DENUB 60MG INJECTION

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DENUB 60MG INJECTION

By ALKEM LABORATORIES LIMITED

MRP

₹

8085.9

₹7331.25

9.33 % OFF

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Product DetailsArrow

Content Reviewed By:

Dr. Anil Gupta

, (MBBS)

Written By:

Mr. Ankit Jain

, (B.Pharm)

About DENUB 60MG INJECTION

  • DENUB 60MG INJECTION contains Denosumab as its active ingredient. It is primarily used in the treatment of osteoporosis, a condition characterized by decreased bone density and increased risk of fractures. Additionally, it is prescribed to prevent skeletal-related events in patients with specific cancers like multiple myeloma and bone metastases from solid tumors. This injection is a targeted therapy designed to strengthen bones and reduce the likelihood of fractures and other bone complications.
  • DENUB 60MG INJECTION functions by targeting and inhibiting RANK ligand, a protein that regulates the activity of osteoclasts, the cells responsible for bone resorption or breakdown. By blocking RANK ligand, DENUB 60MG INJECTION slows down bone resorption, allowing bone density to increase over time. Clinical studies have demonstrated that DENUB 60MG INJECTION can significantly improve bone mineral density, leading to a substantial reduction in fracture risk, particularly in postmenopausal women with osteoporosis. It's a valuable tool in managing bone health and preventing debilitating fractures.
  • Before using DENUB 60MG INJECTION, it's crucial to inform your healthcare provider about any existing medical conditions, allergies, or medications you are currently taking. It is contraindicated in individuals with known hypersensitivity to Denosumab or any of its components. Ensuring adequate calcium and vitamin D intake is essential during treatment with DENUB 60MG INJECTION to support bone health. Patients with pre-existing hypoparathyroidism (low parathyroid hormone levels) should use this medication with caution, as it may exacerbate the condition. Regular monitoring of calcium levels is advisable during treatment.
  • DENUB 60MG INJECTION is not approved for use in children and adolescents under 18 years of age, as its safety and efficacy in these populations have not been established. If you have moderate renal impairment, your renal function may need to be monitored closely during treatment. Always follow your healthcare provider's instructions precisely regarding dosage, administration schedule, and any necessary precautions. This medication is an important part of managing bone health, and adherence to the prescribed regimen is key to achieving the best possible outcomes.

Uses of DENUB 60MG INJECTION

  • DENUB 60MG INJECTION is used in the treatment of the following condition: Osteoporosis. Osteoporosis is a condition characterized by decreased bone density, leading to weakened bones and an increased risk of fractures. This medication helps to strengthen bones and reduce the likelihood of fractures associated with osteoporosis.
  • Bone loss due to hormonal therapy in breast or prostate cancer. Hormonal therapies used in the treatment of breast and prostate cancer can sometimes lead to bone loss as a side effect. DENUB 60MG INJECTION helps to mitigate this bone loss and maintain bone strength in patients undergoing such treatments.
  • Multiple myeloma (cancer affects plasma cells in the bone marrow). Multiple myeloma is a type of cancer that affects plasma cells in the bone marrow. DENUB 60MG INJECTION can be used to help strengthen bones and reduce bone-related complications in patients with multiple myeloma.
  • Bone metastases (cancer that spreads to bone). Bone metastases occur when cancer cells spread from a primary tumor to the bones. DENUB 60MG INJECTION helps to manage bone pain, reduce the risk of fractures, and improve the overall quality of life for individuals with bone metastases.

Side Effects of DENUB 60MG INJECTIONArrow

Like all medications, DENUB 60MG INJECTION can cause side effects, although not everyone experiences them. Serious side effects include osteonecrosis of the jaw (severe necrosis or death of jaw cells), atypical femoral fractures, and hypocalcemia (low blood calcium levels). Common side effects include injection site reactions, back pain, musculoskeletal pain, infections, abdominal pain, headache, and hypophosphatemia (low blood phosphate levels).

  • Osteonecrosis of the jaw (severe necrosis or death of jaw cells)
  • Atypical femoral fractures
  • Hypocalcemia (low blood calcium levels)
  • Injection site reactions
  • Back pain
  • Musculoskeletal pain
  • Infections
  • Abdominal pain
  • Headache
  • Hypophosphatemia (low blood phosphate levels)

Safety Advice for DENUB 60MG INJECTIONArrow

breast_feeding

BreastFeeding

CONSULT YOUR DOCTOR

Whether DENUB 60MG INJECTION is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.

driving

Driving

UNSAFE

Patients receiving DENUB 60MG INJECTION should be advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing a patient's ability to drive or operate machinery safely.

liver

Liver Function

CONSULT YOUR DOCTOR

DENUB 60MG INJECTION is primarily metabolized in the liver, and its safety has not been extensively studied in individuals with severe liver impairment. It is crucial to communicate any pre-existing liver conditions or changes in liver function to your healthcare provider to ensure this medication's safe and effective use.

lungs

Lungs

CONSULT YOUR DOCTOR

If you have a lung or respiratory disorders history, it is important to consult your healthcare provider before taking DENUB 60MG INJECTION.

pregnancy

Pregnancy

CONSULT YOUR DOCTOR

The safety of using DENUB 60MG INJECTION during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.

Dosage of DENUB 60MG INJECTIONArrow

  • DENUB 60MG INJECTION is administered via injection by qualified healthcare professionals, ensuring precise and safe delivery of the medication.
  • The specific dosage regimen, including the amount of medication and the duration of treatment, is carefully determined by a healthcare provider based on a thorough assessment of the patient's individual medical condition and their response to DENUB 60MG INJECTION.
  • It is crucial to adhere strictly to the healthcare provider's instructions regarding dosage and treatment duration to achieve optimal therapeutic benefits and minimize the risk of potential side effects.
  • Self-adjusting the dosage or discontinuing treatment without consulting a healthcare professional can have adverse consequences and is strongly discouraged. This medication is typically administered in a clinical setting where healthcare providers can monitor your progress and address any concerns.
  • The frequency and timing of injections will also be determined by your doctor, and it is important to attend all scheduled appointments.

How to store DENUB 60MG INJECTION?Arrow

  • Keep DENUB 60MG INJ 1ML away from the reach of children and pets.
  • Store DENUB 60MG INJ 1ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of DENUB 60MG INJECTIONArrow

  • DENUB 60MG INJECTION offers a range of significant therapeutic benefits, primarily focused on enhancing bone health and reducing fracture risk. It is particularly effective in individuals suffering from osteoporosis or those identified as being at high risk of developing the condition. The medication works by actively inhibiting bone resorption, a process where old bone tissue is broken down and removed, thanks to its targeted action on RANK ligands. By slowing down this resorption process, DENUB 60MG INJECTION allows bone formation to catch up, leading to a net increase in bone mass and strength.
  • A key therapeutic effect of DENUB 60MG INJECTION is its ability to increase bone mineral density (BMD). BMD is a crucial indicator of bone strength; higher BMD values generally correlate with stronger bones and a lower risk of fractures. Clinical studies have demonstrated that DENUB 60MG INJECTION can significantly improve BMD in various skeletal sites, including the spine and hip, which are common locations for osteoporotic fractures. This increase in BMD contributes directly to the reduced fracture risk observed with this medication.
  • Ultimately, the therapeutic effects of DENUB 60MG INJECTION translate into improved overall bone health and a substantial reduction in the likelihood of fractures. By strengthening bones and increasing their density, this medication helps patients maintain their mobility, independence, and quality of life. It allows them to engage in daily activities with greater confidence and reduces the fear and anxiety associated with potential falls and fractures. The positive impact on bone health contributes to a more active and fulfilling lifestyle for individuals at risk of or suffering from osteoporosis.

How to use DENUB 60MG INJECTIONArrow

  • DENUB 60MG INJECTION is administered by qualified healthcare professionals through injection. It's crucial to understand that the precise dosage and the length of your treatment with this medication will depend heavily on your specific medical condition and how your body responds to the drug. Your healthcare provider is best equipped to assess your individual needs and determine the appropriate treatment plan.
  • Self-administering this injection is strongly discouraged. Only trained medical personnel should handle the administration of DENUB 60MG INJECTION to ensure it is done safely and effectively. They will know the correct injection site, the proper technique, and how to monitor you for any potential side effects.
  • Following your healthcare provider’s instructions meticulously regarding dosage and schedule is paramount for achieving the best possible outcome from your treatment. Do not attempt to alter the dosage or frequency of injections without first consulting your doctor.
  • If you have any concerns or questions about DENUB 60MG INJECTION or its administration, please do not hesitate to discuss them with your healthcare provider. They can provide you with personalized guidance and address any anxieties you may have.

Top Substitutes for DENUB 60MG INJECTION

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OLIMAB 60MG INJ 1MLINTAS PHARMACEUTICALS LIMITED115458.4650057.95
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DENOSTA 60MG INJ 1MLSHILPA BIOSCIENCES PVT LTD125776.56703172.72
ROZEL 60MG INJ 1MLINTAS PHARMACEUTICALS LIMITED115458.4750051.48
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DENSUCOR PFS 60MG INJ 1MLTORRENT PHARMACEUTICALS LIMITED110000850015
DENOCLAST 60MG INJ 1MLZYDUS LIFESCIENCES LIMITED119687875055.55
DENOSTEOREL 60MG INJ 1MLRELIANCE LIFE SCIENCES122687.5880061.21
DENMAB 60MG INJ 1MLEMCURE PHARMACEUTICALS LIMITED118750950049.33
NUCLASTA 60MG INJ 1MLCADILA PHARMACEUTICALS PRIVATE LIMITED118478.13999945.89
DENSURANK 60MG INJ 1MLRPG LIFE SCIENCES LIMITED124232.17999958.74
DENOCI OP 60MG INJ 1MLCIPLA PHARMACEUTICAL COMPANY LIMITED1165001000039.39
ODENSOMAB 60MG INJ 1MLLUPIN LIMITED1183751008045.14
DENAXA 60MG INJ 1MLABBOTT HEALTH CARE PRIVATE LIMITED117531.241010042.39
OGAIN 60MG INJ 1MLZYDUS LIFESCIENCES LIMITED121656.251219743.68
DENINTA 60MG INJ 1MLINTAS PHARMACEUTICALS LIMITED1187501350028
DENBRI 60MG INJ 1MLRPG LIFE SCIENCES LIMITED122031.251369737.83
ESENTRA 60MG INJ 1MLINTAS PHARMACEUTICALS LIMITED1187501425323.98
PROLIA 60MG INJDR REDDY'S LABORATORIES LIMITED119687.51575020
DOMVEL 60MG PFS INJ 1MLERIS LIFESCIENCES LIMITED12192518636.2515
DENOCI 60MG INJ 1MLCIPLA PHARMACEUTICAL COMPANY LIMITED114062.5975030.67
DENUB 60MG INJ 3X1MLALKEM LABORATORIES LIMITED123435.621499936
BIOCLAST PFS 60MG INJ 1MLAGENEXT BIOPHARMA1230001955015
MASDEN 60MG INJ 1MLMASTRO BILOGICALS PVT LTD123000230000

FAQs

Can DENUB 60MG INJECTION be used in patients with a history of cancer?Arrow

DENUB 60MG INJECTION is not recommended in patients with a history of certain cancers, such as multiple myeloma or bone metastases. It is important to discuss your medical history and any previous or current cancer diagnoses with your healthcare provider before starting this medication.

Can DENUB 60MG INJECTION be used in patients with kidney problems?Arrow

DENUB 60MG INJECTION is primarily eliminated through the kidneys, so caution is advised in patients with severe renal impairment or end-stage renal disease. Your healthcare provider will assess the potential risks and benefits based on your renal function.

Can DENUB 60MG INJECTION be used as a treatment for osteoporosis in men?Arrow

Yes, DENUB 60MG INJECTION is approved for the treatment of osteoporosis in men at increased risk of fractures. It can help improve bone density and reduce fracture risk in male patients with osteoporosis.

Can DENUB 60MG INJECTION be used in children and adolescents with osteoporosis?Arrow

DENUB 60MG INJECTION is not approved for use in children and adolescents with osteoporosis. The safety and efficacy of this medication have not been established in this population.

Can DENUB 60MG INJECTION be used in individuals with dental implants?Arrow

DENUB 60MG INJECTION use has been associated with a slightly increased risk of jaw osteonecrosis (ONJ). Suppose you have dental implants or are considering getting them. In that case, it is important to discuss this with your dentist and healthcare provider to assess DENUB 60MG INJECTION's potential risks and benefits.

What Are the Side Effects of DENUB 60MG INJECTION?Arrow

DENUB 60MG INJECTION can cause side effects like injection site reactions, back and musculoskeletal pain, infections, abdominal pain, headache, and low blood phosphate levels. Rare but serious side effects may include osteonecrosis of the jaw, atypical femoral fractures, hypocalcemia, and severe skin reactions.

Does DENUB 60MG INJECTION interact with other drugs?Arrow

There are no known significant interactions of DENUB 60MG INJECTION with other drugs. However, it is important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking to avoid any potential interactions.

What advice should I follow for DENUB 60MG INJECTION?Arrow

Attend all scheduled appointments and follow-up visits to monitor your response to treatment and address any concerns or side effects. Tell your doctor about your medical history, previous infection, liver disease, and kidney disease. Inform your healthcare provider about any allergies or hypersensitivity reactions you may have. Seek immediate medical attention if you experience severe allergic reactions or other serious side effects. Additionally, DENUB 60MG INJECTION may affect calcium levels, so monitoring calcium levels and ensuring adequate calcium and vitamin D intake is important. Pregnant and breastfeeding women should consult a doctor before taking this medication. Avoid taking any vaccines during treatment. Regular dental examinations and good oral hygiene practices are recommended to minimize the risk of jaw osteonecrosis.

What is Denosumab?Arrow

Denosumab is the molecule/combination used for making DENUB 60MG INJECTION. It is a monoclonal antibody that targets a protein called RANKL, which is involved in bone remodeling.

For what ailments/diseases/conditions is DENUB 60MG INJECTION prescribed?Arrow

DENUB 60MG INJECTION is prescribed for ailments/diseases/conditions related to Rheumatology and Orthopaedics. It is used to treat osteoporosis and other conditions related to bone loss.

References

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Amgen Ltd, Electronic medicines compendium (EMC)

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Amgen Manufacturing Limited, US Food and Drug Administration

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Book Icon

Amgen Manufacturing Limited, US Food and Drug Administration

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Marketer / Manufacturer Details

ALKEM LABORATORIES LIMITED

Country of Origin -

India

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