JAKNAT 5MG TABLET 10'S
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JAKNAT 5MG TABLET 10'SJAKNAT 5MG TABLET 10'S
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JAKNAT 5MG TABLET 10'S

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JAKNAT 5MG TABLET 10'S

By NATCO PHARMA LIMITED

MRP

346.87

₹294.84

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Product DetailsArrow

Content Reviewed By:

Dr. Sanjay Mehta

, (MBBS)

Written By:

Ms. Kavita Desai

, (B.Pharm)

About JAKNAT 5MG TABLET 10'S

  • Jaknat 5 is a prescription medicine that contains 5 mg of a Janus kinase (JAK) inhibitor, commonly used in the management of certain immune‑mediated and inflammatory conditions. It is generally prescribed by specialists such as dermatologists, rheumatologists, or gastroenterologists, depending on the approved indication in a particular country. The medicine works by selectively blocking specific JAK enzymes involved in the signaling pathways of various cytokines and growth factors. These pathways play a key role in driving inflammation and abnormal immune responses. By modulating this signaling, Jaknat 5 can help reduce inflammation, control disease activity, and improve symptoms such as redness, swelling, pain, itching, or joint stiffness, depending on the underlying condition. Jaknat 5 is not an over‑the‑counter product and should only be used under the supervision of a qualified healthcare professional. The exact indication, treatment duration, and whether it is used alone or in combination with other medicines (such as conventional disease‑modifying antirheumatic drugs or topical therapies) depend on local regulatory approvals and your doctor’s clinical judgment. Patients should not start, stop, or change the dose of Jaknat 5 on their own. Because JAK inhibitors can affect the immune system, doctors usually perform baseline tests before starting therapy, including complete blood counts, liver and kidney function tests, and screening for infections such as tuberculosis or hepatitis, as per local guidelines. Commonly reported side effects with JAK inhibitors may include upper respiratory tract infections, headache, nausea, diarrhea, elevated cholesterol levels, and changes in blood counts. More serious but less common risks can include serious infections, blood clots, cardiovascular events, and certain malignancies, especially with long‑term use or in high‑risk patients. Therefore, regular follow‑up and laboratory monitoring are important while taking Jaknat 5. Patients should promptly report symptoms such as persistent fever, shortness of breath, chest pain, unusual bruising or bleeding, severe abdominal pain, yellowing of the eyes or skin, or any new or changing skin lesions. Jaknat 5 may interact with other medicines, including some used for infections, seizures, heart conditions, or other immune‑modulating therapies. It is important to inform your doctor about all prescription medicines, over‑the‑counter drugs, herbal products, and supplements you are taking. Vaccination status should be reviewed before starting treatment, as live vaccines are generally avoided during therapy with JAK inhibitors. Jaknat 5 is not suitable for everyone; people with a history of serious recurrent infections, active tuberculosis, severe liver or kidney disease, certain blood disorders, or a history of blood clots or major cardiovascular events may require special caution, dose adjustment, or an alternative treatment. Always rely on your treating physician’s advice and the patient information leaflet provided with the product for guidance specific to your region and condition.

Uses of JAKNAT 5MG TABLET 10'S

  • Rheumatoid arthritis: A chronic inflammatory disorder affecting many joints, including those in the hands and feet.
  • Psoriatic arthritis: A type of arthritis that affects people with psoriasis, causing joint pain and stiffness.
  • Ankylosing spondylitis: An inflammatory disease that, over time, can cause some of the vertebrae in your spine to fuse.
  • Ulcerative colitis: An inflammatory bowel disease (IBD) that causes inflammation and ulcers in your digestive tract.
  • Polyarticular juvenile idiopathic arthritis: A type of arthritis that affects multiple joints in children.
  • Juvenile psoriatic arthritis: A type of arthritis associated with psoriasis that occurs in children.

Side Effects of JAKNAT 5MG TABLET 10'SArrow

Side effects are unwanted symptoms caused by medicines, but not everyone experiences them. JAKNAT 5MG TABLET 10'S can cause both common and serious side effects.

  • Increased cholesterol levels
  • Headache
  • Painful urination
  • Inflammation of the nose
  • Cough
  • Shortness of breath
  • Diarrhea
  • Skin rashes
  • Lung cancer
  • White blood cell cancer
  • Heart attack
  • Fever and chills
  • Blood in the stool
  • Stomach pain or abdominal pain
  • Skin blisters

Safety Advice for JAKNAT 5MG TABLET 10'SArrow

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Allergies

Contraindicated in known hypersensitivity

Jaknat 5 should not be used in patients with a known allergy to its active ingredient or any of the excipients listed in the product leaflet.

Dosage of JAKNAT 5MG TABLET 10'SArrow

  • Your doctor will determine the appropriate dosage and duration of treatment with JAKNAT 5MG TABLET 10'S based on your specific medical condition, its severity, and other relevant factors. It is crucial to adhere strictly to your doctor's instructions regarding the use of this medication.
  • Swallow the tablet whole with a glass of water. Avoid breaking, crushing, or chewing the tablets, as this could affect how the medication is absorbed and works in your body. You can take JAKNAT 5MG TABLET 10'S with or without food, but consistency in when you take it each day can be helpful.
  • Missing doses can reduce the medicine's effectiveness, so try to take JAKNAT 5MG TABLET 10'S at the same time every day to maintain a consistent level of medication in your system. If you have any questions or concerns about how to take JAKNAT 5MG TABLET 10'S, consult with your doctor or pharmacist for clarification.

How to store JAKNAT 5MG TABLET 10'S?Arrow

  • Keep JAKNAT 5MG TAB 1X10 away from the reach of children and pets.
  • Store JAKNAT 5MG TAB 1X10 at room temperature.

Benefits of JAKNAT 5MG TABLET 10'SArrow

  • JAKNAT 5MG TABLET 10'S is classified as a disease-modifying anti-rheumatic drug (DMARD) and belongs to the class of Janus Kinase Inhibitors. These inhibitors target Janus kinases, which are enzymes (specifically, tyrosine kinases) crucial for cytokine receptor signaling pathways. Cytokines play a vital role in immune responses and inflammation, and their signals are transmitted through the Janus kinase-STAT pathway. By selectively inhibiting Janus kinases, JAKNAT 5MG TABLET 10'S disrupts this signaling cascade.
  • This interference impacts the transcription of genes responsible for cell growth, differentiation, and immune function. In simpler terms, it helps to regulate the overactive immune system that is characteristic of certain autoimmune diseases. This action ultimately reduces inflammation and alleviates the symptoms associated with these conditions.
  • By modulating the activity of Janus kinases, JAKNAT 5MG TABLET 10'S helps to restore balance to the immune system and reduce the damaging effects of chronic inflammation. This can lead to significant improvements in joint pain, swelling, and overall function for individuals suffering from rheumatoid arthritis and other related conditions.

How to use JAKNAT 5MG TABLET 10'SArrow

  • Your doctor will determine the appropriate dosage and treatment duration based on your specific medical condition, its severity, and other relevant factors. It is crucial to adhere to your doctor's prescribed instructions for taking JAKNAT 5MG TABLET 10'S.
  • To ensure optimal absorption and effectiveness, swallow the tablet whole with a full glass of water. Avoid breaking, crushing, or chewing the tablet, as this may alter its intended release mechanism and potentially affect its efficacy.
  • JAKNAT 5MG TABLET 10'S can be taken either with or without food. If you have a sensitive stomach, taking it with a meal might help to minimize any potential gastrointestinal discomfort. However, consistency is key, so try to take it around the same time each day to maintain a stable level of the medication in your system.
  • If you have any questions or concerns regarding the proper way to take JAKNAT 5MG TABLET 10'S, please do not hesitate to consult your doctor or pharmacist. They can provide personalized guidance based on your individual needs and medical history. Never adjust the dosage or frequency of administration without first consulting with your healthcare provider.

FAQs

What are the cautions of JAKNAT 5MG TABLET 10'S?Arrow

Tell your doctor immediately if you start to have swelling of your face, lips, tongue, throat, arms, or legs or if you are having trouble swallowing or breathing. JAKNAT 5MG TABLET 10'S can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection.

Does JAKNAT 5MG TABLET 10'S cause high cholesterol?Arrow

Increased cholesterol levels are one of the side effects of JAKNAT 5MG TABLET 10'S, your doctor may take regular blood tests to check for serious side effects.

Can JAKNAT 5MG TABLET 10'S cause depression?Arrow

No, JAKNAT 5MG TABLET 10'S does not cause depression. However, many people who have autoimmune conditions also have symptoms of depression. If you're having symptoms of depression, see your doctor right away.

Does JAKNAT 5MG TABLET 10'S cause blood clots?Arrow

Yes, blood clots are reported in patients using JAKNAT 5MG TABLET 10'S for a longer period. Inform your physician if you face any symptoms of a blood clot.

How long does it take JAKNAT 5MG TABLET 10'S to work?Arrow

JAKNAT 5MG TABLET 10'S is a long-term treatment. Most people who benefit from this treatment will notice an improvement in the first 12 weeks of starting treatment.

What are the drug interactions of JAKNAT 5MG TABLET 10'S?Arrow

There is no known interaction of JAKNAT 5MG TABLET 10'S with other drugs.

What advice should I follow while taking JAKNAT 5MG TABLET 10'S?Arrow

This medicine may interfere with vaccines, inform your physician about your vaccination history. This medicine may impair fertility; talk to your doctor before taking this medicine. Your doctor will regularly do lab tests to check whether the medicine is working. Do not breastfeed during the treatment with this medicine and for at least 36 hours after your last dose. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury.

What molecule/combination is used for making JAKNAT 5MG TABLET 10'S?Arrow

TOFACITINIB is molecule/combination used for making JAKNAT 5MG TABLET 10'S.

For what ailments/diseases/conditions is JAKNAT 5MG TABLET 10'S prescribed?Arrow

JAKNAT 5MG TABLET 10'S is prescribed for ailments/diseases/conditions related to Rheumatology.

Does JAKNAT 5MG TABLET 10'S help with bone problems?Arrow

JAKNAT 5MG TABLET 10'S is prescribed for ailments/diseases/conditions related to Orthopaedics.

What is Jaknat 5 used for?Arrow

Jaknat 5 contains a Janus kinase (JAK) inhibitor used to manage certain immune‑mediated and inflammatory conditions, such as some forms of arthritis, skin diseases, or other autoimmune disorders, depending on local regulatory approvals. The exact indication for you should be confirmed by your prescribing doctor, who will base the decision on your diagnosis, disease severity, and treatment history.

How does Jaknat 5 work in the body?Arrow

Jaknat 5 works by selectively inhibiting specific Janus kinase (JAK) enzymes that transmit signals from cytokines and growth factors involved in inflammation and immune responses. By dampening these signaling pathways, the medicine helps reduce abnormal immune activity, thereby decreasing inflammation, improving symptoms such as pain, swelling, or itching, and helping to control disease progression in certain conditions.

How should I take Jaknat 5?Arrow

You should take Jaknat 5 exactly as prescribed by your doctor and as described in the patient information leaflet supplied with the medicine. Do not change the dose, frequency, or duration of treatment on your own. Swallow the tablet with water, with or without food, unless your doctor advises otherwise. If you miss a dose, follow your doctor’s instructions or the leaflet guidance rather than doubling the next dose. Never share this medicine with others, even if they have similar symptoms.

Is Jaknat 5 safe for the liver?Arrow

Jaknat 5, like other JAK inhibitors, can affect liver function in some patients. Elevations in liver enzymes may occur and are usually detected through routine blood tests. People with pre‑existing liver disease or a history of hepatitis require particular caution and closer monitoring. Your doctor will typically check liver function before starting treatment and at regular intervals thereafter. If you develop symptoms such as yellowing of the skin or eyes, dark urine, severe fatigue, or right‑upper abdominal pain, contact your doctor immediately. Dose adjustment, temporary interruption, or discontinuation may be needed if significant liver abnormalities occur.

Can patients with kidney problems take Jaknat 5?Arrow

Patients with kidney impairment may be able to take Jaknat 5, but they often require careful assessment and possible dose adjustment, depending on the severity of kidney dysfunction and local prescribing information. Reduced kidney function can influence how the drug is cleared from the body, which may increase the risk of side effects. Your doctor will usually evaluate kidney function with blood tests before starting therapy and periodically during treatment. People with severe kidney disease or on dialysis may need alternative options or very specific dosing recommendations, so they must follow specialist advice closely.

Is Jaknat 5 safe during pregnancy?Arrow

Use of Jaknat 5 during pregnancy is generally not recommended unless the potential benefit clearly outweighs the potential risk to the unborn baby, based on your doctor’s judgment and available local guidance. Data on JAK inhibitors in pregnancy are limited, and there may be concerns about effects on fetal development and the immune system. Women of childbearing potential are usually advised to use effective contraception during treatment and for a period after stopping the medicine, as recommended in the product information. If you are pregnant, planning to become pregnant, or think you might be pregnant while taking Jaknat 5, you should inform your doctor immediately to discuss the safest course of action.

Can I use Jaknat 5 while breastfeeding?Arrow

The safety of Jaknat 5 during breastfeeding is not well established, and it is not known to what extent the active substance passes into human breast milk. Because of the potential for serious adverse reactions in a nursing infant, use during breastfeeding is generally not recommended unless your doctor decides that the benefit to the mother outweighs the possible risk to the child. Your doctor may advise you either to avoid breastfeeding while on Jaknat 5 or to consider an alternative treatment. Always discuss your breastfeeding plans with your healthcare provider before starting or continuing this medicine.

Is it safe to drive or operate machines while taking Jaknat 5?Arrow

Jaknat 5 is not primarily known to impair the ability to drive or use machines in most patients. However, some people may experience side effects such as dizziness, fatigue, or headache, which could affect concentration and reaction time. Until you know how Jaknat 5 affects you, it is sensible to be cautious with activities that require full alertness, such as driving, operating heavy machinery, or working at heights. If you feel unusually tired, dizzy, or unwell after taking the medicine, avoid such activities and consult your doctor.

Can I drink alcohol while taking Jaknat 5?Arrow

Moderate alcohol intake may be permissible for some patients on Jaknat 5, but it should be approached with caution, especially in those with existing liver problems or other risk factors. Both alcohol and JAK inhibitors can place additional strain on the liver, and excessive alcohol consumption may increase the risk of liver damage or worsen side effects such as dizziness or gastrointestinal upset. It is advisable to discuss your alcohol consumption honestly with your doctor, who can provide individualized guidance. Avoid binge drinking and seek medical advice if you notice symptoms suggestive of liver or general health problems.

What if I have allergies or had a reaction to similar medicines before taking Jaknat 5?Arrow

You should not take Jaknat 5 if you are known to be allergic to its active ingredient or any of the excipients listed in the product leaflet. Inform your doctor about any previous allergic reactions to medicines, especially other JAK inhibitors or immunomodulatory drugs. Signs of a serious allergic reaction can include rash, itching, swelling of the face, lips, tongue, or throat, severe dizziness, or difficulty breathing. If any of these occur after taking Jaknat 5, seek emergency medical help immediately and do not take further doses until you have been evaluated. Your doctor may recommend an alternative treatment if you are at high risk of hypersensitivity.

What important precautions should I follow while using Jaknat 5?Arrow

Before and during treatment with Jaknat 5, your doctor will usually check for infections, perform blood tests to monitor blood counts, liver and kidney function, and may assess your cardiovascular and clotting risk. Inform your doctor if you have a history of tuberculosis, hepatitis, recurrent infections, blood clots, heart attack, stroke, cancer, or gastrointestinal perforation. Avoid live vaccines while on therapy and tell any healthcare professional treating you that you are taking a JAK inhibitor. Report symptoms such as persistent fever, weight loss, night sweats, shortness of breath, chest pain, leg swelling, severe abdominal pain, or unusual bruising without delay. Do not stop or restart Jaknat 5 without medical advice.

References

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XELJANZ 5 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk.

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HIGHLIGHTS OF PRESCRIBING INFORMATION - Tofacitinib.

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ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS - Tofacitinib.

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Marketer / Manufacturer Details

NATCO PHARMA LIMITED

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India

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