SIAGLIDE TRIO 10/100/1000MG TABLET 10'S

How SIAGLIDE TRIO 10/100/1000MG TABLET 10'S Works

• SIAGLIDE TRIO 10/100/1000MG TABLET 10'S is a combination medication designed to manage type 2 diabetes mellitus effectively. It combines three active ingredients: Sitagliptin, Metformin, and Pioglitazone, each working through different mechanisms to control blood sugar levels. By addressing multiple pathways involved in glucose regulation, SIAGLIDE TRIO offers a comprehensive approach to managing hyperglycemia.
• Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, enhances the body's natural ability to lower blood sugar. DPP-4 enzymes break down incretin hormones, such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). These hormones are released by the intestine in response to food intake and stimulate insulin release from the pancreas while suppressing glucagon secretion from the liver. By inhibiting DPP-4, Sitagliptin increases the levels of active incretin hormones in the body. This leads to increased insulin release when blood sugar is high and decreased glucagon secretion, resulting in better blood sugar control, especially after meals.
• Metformin, a biguanide, is a cornerstone medication for type 2 diabetes. It primarily works by reducing glucose production in the liver. The liver is a significant source of glucose, especially during fasting and between meals. Metformin suppresses hepatic glucose production by inhibiting gluconeogenesis (the formation of glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Additionally, Metformin improves insulin sensitivity in peripheral tissues like muscles, allowing them to utilize glucose more efficiently. This dual action of reducing glucose production and enhancing insulin sensitivity helps lower blood sugar levels.
• Pioglitazone, a thiazolidinedione (TZD), works by improving insulin sensitivity in peripheral tissues, particularly in muscle and adipose tissue. It activates peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor that plays a crucial role in glucose and lipid metabolism. Activation of PPARγ enhances the responsiveness of cells to insulin, promoting glucose uptake and utilization in muscles and reducing insulin resistance. Pioglitazone also helps to decrease hepatic glucose production and can improve lipid profiles. This results in improved blood sugar control and potentially beneficial effects on cardiovascular risk factors.
• The synergistic action of Sitagliptin, Metformin, and Pioglitazone in SIAGLIDE TRIO provides a multi-pronged approach to managing type 2 diabetes. Sitagliptin enhances insulin secretion and suppresses glucagon, Metformin reduces hepatic glucose production and improves insulin sensitivity, and Pioglitazone further enhances insulin sensitivity in peripheral tissues. This combination helps to address the underlying metabolic defects associated with type 2 diabetes, leading to better glycemic control compared to monotherapy with any of these agents alone. Patients using SIAGLIDE TRIO should adhere to their prescribed dosage, diet, and exercise regimen for optimal results.

Common side effects of SIAGLIDE TRIO 10/100/1000MG TABLET may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, hypoglycemia (low blood sugar), headache, dizziness, and skin rash. Less common but potentially serious side effects can include lactic acidosis (symptoms like weakness, muscle pain, trouble breathing, stomach pain with nausea and vomiting, feeling cold, dizziness, or lightheadedness), liver problems (symptoms like yellowing of the skin or eyes, dark urine, persistent nausea, unusual tiredness), and allergic reactions (symptoms like rash, itching, swelling, severe dizziness, or trouble breathing). Other possible side effects are constipation, flatulence and vitamin B12 deficiency. Contact your doctor immediately if you experience any severe or persistent side effects.

• If you miss a dose of SIAGLIDE TRIO 10/100/1000MG TABLET, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double your dose to make up for the missed one.

• Keep SIAGLIDE TRIO 10/100/1000MG TAB 1X10 away from the reach of children and pets.
• Store SIAGLIDE TRIO 10/100/1000MG TAB 1X10 at room temperature.

• Take SIAGLIDE TRIO 10/100/1000MG TABLET 10'S exactly as prescribed by your doctor. Do not alter the dosage or stop taking the medication without consulting your healthcare provider. This ensures you maintain stable blood sugar levels and maximize the medication's effectiveness.
• It is best to take SIAGLIDE TRIO 10/100/1000MG TABLET 10'S with food to minimize the risk of stomach upset. Taking it at the same time each day will also help you remember to take it regularly and maintain consistent drug levels in your body.
• Regularly monitor your blood sugar levels as directed by your doctor while taking SIAGLIDE TRIO 10/100/1000MG TABLET 10'S. This will help you and your doctor understand how well the medication is working and adjust the treatment plan if necessary. Keep a log of your readings to share with your healthcare provider.
• Stay hydrated and maintain a healthy lifestyle while on SIAGLIDE TRIO 10/100/1000MG TABLET 10'S. Drink plenty of water throughout the day and follow a balanced diet rich in fiber, fruits, and vegetables. Regular physical activity can also improve blood sugar control and overall health. Avoid excessive alcohol consumption, as it can interfere with the medication's effects and increase the risk of side effects.
• Be aware of the potential side effects of SIAGLIDE TRIO 10/100/1000MG TABLET 10'S, such as nausea, diarrhea, or hypoglycemia (low blood sugar). If you experience any severe or persistent side effects, contact your doctor immediately. Carry a source of fast-acting glucose (e.g., glucose tablets or fruit juice) with you in case of hypoglycemia.

• SIAGLIDE TRIO 10/100/1000MG TABLET 10'S should be taken with food to decrease the chance of an upset stomach. High fat meals may decrease the absorption of metformin, one of the medicines in this tablet, so moderation is advised. Consult your doctor for specific dietary advice while taking this medication.