XIGDUO XR 10/500MG TABLET 7'S
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XIGDUO XR 10/500MG TABLET 7'S

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XIGDUO XR 10/500MG TABLET 7'S

By ASTRAZENECA PHARMA INDIA LIMITED

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About XIGDUO XR 10/500MG TABLET 7'S

  • XIGDUO XR 10/500MG TABLET is a prescription medication designed to help adults with type 2 diabetes manage their blood sugar levels. It combines two powerful active ingredients: dapagliflozin and metformin hydrochloride. This combination therapy works through complementary mechanisms to improve glycemic control when diet and exercise alone are not sufficient.
  • Dapagliflozin belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It works by preventing the kidneys from reabsorbing glucose back into the blood. Instead, the excess glucose is excreted in the urine, effectively lowering blood sugar levels. This process also offers the added benefit of calorie loss, which can contribute to weight management.
  • Metformin hydrochloride, on the other hand, is a biguanide that primarily reduces glucose production in the liver. It also improves the body's sensitivity to insulin, allowing cells to use glucose more effectively. Metformin is a well-established drug in diabetes management and has been used for decades.
  • XIGDUO XR is an extended-release formulation, meaning it releases the medication slowly into the body over time. This helps to maintain stable blood sugar levels throughout the day and reduces the frequency of dosing. Typically, it is taken once daily with a meal.
  • It's crucial to use XIGDUO XR as directed by your healthcare provider. This includes following their instructions on dosage, timing, and any necessary lifestyle modifications, such as diet and exercise. Regular monitoring of blood sugar levels is also essential to ensure the medication is working effectively and to detect any potential side effects.
  • Always consult with your doctor or pharmacist for any questions related to XIGDUO XR 10/500MG TABLET. They can provide guidance tailored to your individual health condition and ensure safe and effective use of the medication. This medication is typically used along with lifestyle changes such as diet and excercise.

Uses of XIGDUO XR 10/500MG TABLET 7'S

  • Treatment of type 2 diabetes mellitus
  • Control of blood sugar levels
  • Used in conjunction with diet and exercise
  • For the treatment of type 2 diabetes in adults
  • Not suitable for use in patients with kidney disease

How XIGDUO XR 10/500MG TABLET 7'S Works

  • XIGDUO XR 10/500MG TABLET 7'S is a combination medication designed to manage blood sugar levels in adults with type 2 diabetes. It contains two active ingredients: dapagliflozin and metformin hydrochloride. These two medications work through different mechanisms to provide comprehensive glycemic control. Dapagliflozin belongs to a class of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. SGLT2 inhibitors work in the kidneys to reduce the reabsorption of glucose, leading to increased glucose excretion in the urine. By blocking the SGLT2 protein, dapagliflozin prevents the kidneys from reabsorbing glucose back into the bloodstream. This results in lower blood sugar levels and can also lead to some weight loss and blood pressure reduction.
  • Metformin hydrochloride is a biguanide, a well-established medication for type 2 diabetes. Metformin primarily works by decreasing glucose production in the liver. It achieves this by suppressing hepatic gluconeogenesis, the process by which the liver produces glucose from non-carbohydrate sources. Additionally, metformin improves insulin sensitivity in peripheral tissues, such as muscles and fat. This means that the body's cells become more responsive to insulin, allowing them to take up glucose from the bloodstream more effectively. Metformin also slows down the absorption of glucose from the intestines after meals, further contributing to blood sugar control.
  • The combination of dapagliflozin and metformin in XIGDUO XR offers a synergistic effect. Dapagliflozin reduces glucose reabsorption in the kidneys, while metformin reduces glucose production in the liver and improves insulin sensitivity. This dual mechanism helps to lower both fasting and post-meal blood sugar levels. The 'XR' in XIGDUO XR stands for extended-release, meaning the medication is released slowly into the body over time. This allows for once-daily dosing, which can improve patient compliance and convenience. By taking XIGDUO XR as prescribed and in conjunction with diet and exercise, individuals with type 2 diabetes can effectively manage their blood sugar levels, reduce the risk of diabetes-related complications, and improve their overall health.

Side Effects of XIGDUO XR 10/500MG TABLET 7'SArrow

XIGDUO XR 10/500MG TABLET 7'S can cause several side effects, ranging from common to rare. Common side effects include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and metallic taste. You might also experience upper respiratory tract infection symptoms like a sore throat or runny nose, as well as headaches. Genital fungal infections are another potential side effect. Less common but more serious side effects include lactic acidosis (symptoms like rapid breathing, stomach pain, and feeling weak or tired), kidney problems, and pancreatitis (severe stomach pain that may spread to your back). Allergic reactions, such as rash, itching, or swelling, are also possible. In rare cases, it can lead to diabetic ketoacidosis (symptoms like excessive thirst, frequent urination, and confusion) or serious urinary tract infections. It's important to contact your doctor immediately if you experience any severe or persistent side effects.

Safety Advice for XIGDUO XR 10/500MG TABLET 7'SArrow

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Allergies

Allergies

Do not use XIGDUO XR 10/500MG TABLET 7'S if you are allergic to it.

Dosage of XIGDUO XR 10/500MG TABLET 7'SArrow

  • The recommended dosage of XIGDUO XR 10/500MG TABLET 7'S is individualized based on the patient's current antidiabetic treatment regimen, effectiveness, and tolerability, not exceeding the maximum recommended daily dose of 10 mg dapagliflozin and 2000 mg metformin hydrochloride. Generally, it is taken once daily with the evening meal. Patients already on metformin should start XIGDUO XR 10/500MG TABLET 7'S at a dose that provides the daily dose of dapagliflozin (10 mg) and a similar total daily dose of metformin as they were already taking or the nearest therapeutically appropriate dose.
  • For patients not currently treated with metformin, the recommended starting dose is 10 mg dapagliflozin/500 mg metformin hydrochloride extended-release once daily, with gradual dose escalation to reduce gastrointestinal side effects associated with metformin. The dose can be increased gradually as needed to achieve adequate glycemic control, up to a maximum of 10 mg dapagliflozin/2000 mg metformin hydrochloride extended-release once daily.
  • It is crucial to swallow XIGDUO XR 10/500MG TABLET 7'S whole and never crush, cut, or chew the tablets. This ensures the extended-release mechanism functions correctly, allowing for a steady release of medication over time. Regular monitoring of kidney function is advised before initiating XIGDUO XR 10/500MG TABLET 7'S and periodically thereafter. Dosage adjustments may be needed in patients with renal impairment. Always consult your doctor for personalized dosage instructions. Take 'XIGDUO XR 10/500MG TABLET 7'S' only as per the prescription by your physician only.

What if I miss my dose of XIGDUO XR 10/500MG TABLET 7'S?Arrow

  • If you miss a dose of XIGDUO XR, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

How to store XIGDUO XR 10/500MG TABLET 7'S?Arrow

  • Keep XIGDUO XR 10/500MG TAB 1X7 away from the reach of children and pets.
  • Store XIGDUO XR 10/500MG TAB 1X7 at room temperature.

Benefits of XIGDUO XR 10/500MG TABLET 7'SArrow

  • XIGDUO XR 10/500MG TABLET 7'S offers a dual-action approach to managing type 2 diabetes by combining two powerful medications: dapagliflozin and metformin. This combination provides several benefits that help patients achieve better glycemic control and improve their overall health.
  • One of the primary benefits of XIGDUO XR is its ability to effectively lower blood sugar levels. Dapagliflozin, an SGLT2 inhibitor, works by preventing the kidneys from reabsorbing glucose back into the blood. Instead, excess glucose is excreted through urine, leading to a reduction in blood sugar levels. Metformin, on the other hand, reduces glucose production in the liver and improves insulin sensitivity, allowing the body to use insulin more effectively. Together, these mechanisms ensure a comprehensive approach to blood sugar management.
  • XIGDUO XR not only lowers blood sugar but also helps in weight management. Dapagliflozin's mechanism of action leads to the excretion of calories through urine, which can result in modest weight loss. This can be particularly beneficial for individuals with type 2 diabetes who are also struggling with obesity or overweight issues. Metformin also contributes to weight management by improving metabolic processes and reducing appetite.
  • Cardiovascular benefits are another significant advantage of XIGDUO XR. Studies have shown that dapagliflozin can reduce the risk of cardiovascular events, such as heart attack and stroke, in patients with type 2 diabetes who also have established cardiovascular disease or multiple cardiovascular risk factors. This makes XIGDUO XR a valuable option for individuals at high risk of heart-related complications.
  • XIGDUO XR offers the convenience of a once-daily dosage, which can improve medication adherence. Taking a single tablet each day simplifies the treatment regimen and makes it easier for patients to incorporate it into their daily routine. This can lead to better glycemic control and improved long-term outcomes.
  • Furthermore, XIGDUO XR can improve blood pressure control. Dapagliflozin has been shown to have a mild diuretic effect, which can help lower blood pressure. This is particularly beneficial for individuals with type 2 diabetes who also have hypertension, a common comorbidity.
  • XIGDUO XR can also lead to improvements in HbA1c levels, a measure of average blood sugar over the past 2-3 months. By effectively lowering blood sugar, XIGDUO XR helps patients achieve and maintain target HbA1c levels, reducing the risk of long-term complications associated with diabetes.
  • Finally, XIGDUO XR can offer renal protection. Studies suggest that dapagliflozin may have protective effects on the kidneys, slowing the progression of diabetic kidney disease. This is a crucial benefit for individuals with diabetes, as kidney disease is a common and serious complication.

How to use XIGDUO XR 10/500MG TABLET 7'SArrow

  • XIGDUO XR 10/500MG TABLET 7'S should be taken orally, once daily, preferably with a meal to minimize gastrointestinal discomfort. Swallow the tablet whole; do not crush, cut, or chew it. This medication is designed for extended release, and altering the tablet can disrupt this mechanism, potentially leading to a rapid release of the drug and increasing the risk of side effects.
  • The dosage of XIGDUO XR is individualized based on your doctor's assessment of your blood sugar levels, overall health, and response to treatment. It is crucial to adhere strictly to the prescribed dosage and timing. Do not adjust the dosage yourself without consulting your healthcare provider.
  • Consistency is key when taking XIGDUO XR. Try to take it at the same time each day to maintain a steady level of medication in your bloodstream. If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
  • While taking XIGDUO XR, it's important to maintain a healthy lifestyle, including a balanced diet and regular exercise. This medication works best when combined with these lifestyle modifications. Monitor your blood sugar levels regularly as directed by your doctor, and report any unusual symptoms or side effects promptly.
  • Keep XIGDUO XR in its original packaging, stored at room temperature, away from moisture and direct sunlight. Keep it out of reach of children. Before starting XIGDUO XR, inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins, as drug interactions may occur. Also, disclose any pre-existing medical conditions you have, especially kidney or liver problems. Regular checkups and blood tests are necessary to monitor your kidney function while on this medication.

Quick Tips for XIGDUO XR 10/500MG TABLET 7'SArrow

  • **Take XIGDUO XR 10/500MG TABLET 7'S as prescribed:** Always follow your doctor's instructions regarding dosage and timing. Do not alter the dosage without consulting your healthcare provider. This ensures optimal blood sugar control and minimizes potential side effects. Taking it at the same time each day helps maintain consistent medication levels in your body.
  • **Administer with Food:** It is generally recommended to take XIGDUO XR 10/500MG TABLET 7'S with food, especially breakfast. This helps to reduce the likelihood of gastrointestinal discomfort, a common side effect of metformin. Eating with the medication also aids in the absorption process and promotes steady blood sugar levels.
  • **Stay Hydrated:** While taking XIGDUO XR 10/500MG TABLET 7'S, maintain adequate hydration by drinking plenty of water throughout the day, unless advised otherwise by your doctor. Adequate hydration supports kidney function, which is important since metformin is processed by the kidneys. Aim for at least 8 glasses of water daily.
  • **Monitor Blood Sugar Regularly:** Keep a close eye on your blood sugar levels as directed by your doctor. Regular monitoring is crucial to assess how well the medication is working. Share your readings with your healthcare provider to make informed decisions about your treatment plan. Consistent monitoring aids in identifying patterns and adjusting medication as needed.
  • **Be Aware of Potential Side Effects:** Be vigilant for any side effects, such as nausea, diarrhea, or abdominal discomfort. More serious side effects include lactic acidosis, a rare but potentially life-threatening condition. Seek immediate medical attention if you experience symptoms like unusual muscle pain, difficulty breathing, or severe weakness. Knowing potential side effects helps you act quickly if something is amiss.

Food Interactions with XIGDUO XR 10/500MG TABLET 7'SArrow

  • XIGDUO XR 10/500MG TABLET 7'S should be taken with food to decrease the chance of an upset stomach.
  • Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of lactic acidosis, a serious side effect.

FAQs

What is XIGDUO XR 10/500MG TABLET 7'S?Arrow

XIGDUO XR 10/500MG TABLET 7'S is a combination of two medicines: Dapagliflozin and Metformin. It is used to control blood sugar levels in adults with type 2 diabetes mellitus.

What is XIGDUO XR 10/500MG TABLET 7'S used for?Arrow

XIGDUO XR 10/500MG TABLET 7'S is used to control high blood sugar levels in people with type 2 diabetes along with proper diet and exercise.

What are the common side effects of XIGDUO XR 10/500MG TABLET 7'S?Arrow

Common side effects of XIGDUO XR 10/500MG TABLET 7'S include nausea, vomiting, diarrhea, abdominal pain, and loss of appetite.

Is XIGDUO XR 10/500MG TABLET 7'S harmful to the kidneys?Arrow

XIGDUO XR 10/500MG TABLET 7'S should be used with caution in patients with kidney problems. Patients with a history of kidney disease should consult their doctor before taking this medication.

How to store XIGDUO XR 10/500MG TABLET 7'S?Arrow

Store XIGDUO XR 10/500MG TABLET 7'S at room temperature, away from direct sunlight and heat. Keep it out of reach of children and pets.

Is XIGDUO XR 10/500MG TABLET 7'S safe during pregnancy?Arrow

The safety of XIGDUO XR 10/500MG TABLET 7'S during pregnancy has not been established. Pregnant women should consult their doctor before taking this medication.

Is XIGDUO XR 10/500MG TABLET 7'S safe during breastfeeding?Arrow

The safety of XIGDUO XR 10/500MG TABLET 7'S during breastfeeding has not been established. Breastfeeding women should consult their doctor before taking this medication.

What happens if I miss a dose of XIGDUO XR 10/500MG TABLET 7'S?Arrow

If you miss a dose of XIGDUO XR 10/500MG TABLET 7'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time.

Does XIGDUO XR 10/500MG TABLET 7'S cause weight gain?Arrow

XIGDUO XR 10/500MG TABLET 7'S does not usually cause weight gain. It may cause weight loss in some patients.

Should XIGDUO XR 10/500MG TABLET 7'S be taken with food?Arrow

XIGDUO XR 10/500MG TABLET 7'S can be taken with or without food, but it is best to take it at the same time each day.

What are the alternatives to XIGDUO XR 10/500MG TABLET 7'S?Arrow

Alternatives to XIGDUO XR 10/500MG TABLET 7'S include other diabetes medications, such as a combination of glimepiride and metformin (e.g., Glimepiride/Metformin). Consult with your doctor.

Can I drink alcohol with XIGDUO XR 10/500MG TABLET 7'S?Arrow

Avoid drinking alcohol with XIGDUO XR 10/500MG TABLET 7'S, as it can lower blood sugar levels and increase the risk of other side effects.

Does XIGDUO XR 10/500MG TABLET 7'S cause dizziness?Arrow

Yes, XIGDUO XR 10/500MG TABLET 7'S can cause dizziness in some people. If you experience dizziness, avoid driving or operating machinery.

What happens if I overdose on XIGDUO XR 10/500MG TABLET 7'S?Arrow

If you overdose on XIGDUO XR 10/500MG TABLET 7'S, seek immediate medical attention. Symptoms of an overdose may include nausea, vomiting, abdominal pain, weakness, and dizziness.

Does XIGDUO XR 10/500MG TABLET 7'S interact with other medications?Arrow

XIGDUO XR 10/500MG TABLET 7'S can interact with certain other medications, such as insulin, sulfonylureas, and diuretics. Tell your doctor about all the medications you are taking.

References

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XIGDUO XR (metformin hydrochloride and dapagliflozin) extended-release tablets. US FDA Label.

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Metformin. DrugBank Online.

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Dapagliflozin. DrugBank Online.

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Dapagliflozin: A review of its use in the treatment of type 2 diabetes mellitus. PMC, National Institutes of Health.

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Xigduo. European Medicines Agency.

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Metformin. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases.

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Safety and efficacy of dapagliflozin add-on to metformin in Asian patients with type 2 diabetes mellitus. PubMed.

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