ADVAMAB 400 INJECTION
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ADVAMAB 400 INJECTION
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ADVAMAB 400 INJECTION

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ADVAMAB 400 INJECTION

By ALKEM LABORATORIES LIMITED

MRP

₹

45870

₹18150

60.43 % OFF

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Product DetailsArrow

About ADVAMAB 400 INJECTION

  • ADVAMAB 400 INJECTION is an anticancer medicine containing Bevacizumab. It is designed to inhibit tumor growth and is used alongside other chemotherapy drugs to treat various cancers, including metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It also treats cancers of the ovary, fallopian tube, or primary peritoneal cancer.
  • During treatment with ADVAMAB 400 INJECTION and for at least six months after the final dose, it is crucial to use effective birth control methods. This medication is not recommended for children and adolescents under 18 years old. If you plan to have children in the future, discuss options for ovary preservation with your doctor, as ADVAMAB 400 INJECTION may impair fertility in women. Breastfeeding is not advised while using this medicine, as it can interfere with the baby's growth and development.
  • ADVAMAB 400 INJECTION is commonly administered in combination with other chemotherapy agents. Common side effects include constipation, loss of appetite, runny nose, fever, skin problems, and weight loss. Inform your doctor about any pre-existing conditions such as high blood pressure, high blood sugar, stomach disorders, or heart problems before starting treatment. Avoid taking this medicine for 28 days before and after surgery due to the risk of poor wound healing and increased bleeding complications. Report any dental issues requiring surgery to your doctor before starting ADVAMAB 400 INJECTION treatment. Immediately report any visual changes or confusion to your doctor to prevent potential complications.
  • This medication works by targeting a protein called vascular endothelial growth factor (VEGF). VEGF helps tumors grow new blood vessels so they can get the nutrients they need to grow and spread. By blocking VEGF, ADVAMAB 400 INJECTION can help slow or stop the growth of certain cancers. Regular monitoring by your healthcare provider is essential to manage potential side effects and ensure the treatment's effectiveness. Ensure you attend all scheduled appointments and openly communicate any concerns or changes in your health.

Uses of ADVAMAB 400 INJECTION

  • ADVAMAB 400 INJECTION is indicated to treat the following conditions: Glioblastoma multiforme (brain cancer). This is a type of aggressive brain tumor that originates from glial cells.
  • Persistent, recurrent, or metastatic breast cancer. This refers to breast cancer that has returned after treatment, continues to grow, or has spread to other parts of the body.
  • Metastatic cervical cancer. This indicates cervical cancer that has spread from the cervix to distant sites in the body.
  • Advanced kidney cancer. This refers to kidney cancer that has spread beyond the kidney to nearby tissues or distant organs.
  • Metastatic colorectal cancer. This means colorectal cancer that has spread to other parts of the body, typically the liver or lungs.
  • Advanced non-small-cell lung cancer. This indicates a type of lung cancer that is in a later stage and has spread beyond the lung.
  • Liver Cancer- Hepatocellular carcinoma. This is a primary cancer of the liver, originating from the hepatocytes.
  • Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer. This includes various gynecological cancers affecting the female reproductive organs and the lining of the abdomen.

Side Effects of ADVAMAB 400 INJECTIONArrow

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

  • Headache
  • Vision changes
  • Confusion
  • Severe allergic reactions
  • High Blood pressure
  • Delayed wound healing following surgery
  • Protein in urine
  • Severe infections
  • Blood clots in arteries and blood vessels of lungs
  • Gut perforation
  • Nosebleeds and bleeding risk
  • Heart problems with an increase in heart rate
  • Mouth sores, dryness
  • Shortness of breath
  • Numbness in hands or feet
  • Weakness and lack of energy
  • Diarrhoea, nausea, vomiting, abdominal pain
  • Constipation
  • Loss of appetite
  • Weight loss
  • Changes in taste and speech
  • Decrease in counts of white blood cells
  • Fever
  • Dry skin
  • Back pain

Safety Advice for ADVAMAB 400 INJECTIONArrow

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Pregnancy

UNSAFE

Inform your physician before starting your treatment with ADVAMAB 400 INJECTION in case, if you are pregnant or planning for pregnancy as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.

Dosage of ADVAMAB 400 INJECTIONArrow

  • Your physician or nurse will administer ADVAMAB 400 INJECTION as an intravenous infusion. The infusion should be given immediately after dilution to ensure the medication's stability and effectiveness.
  • The healthcare provider will carefully calculate the correct dosage based on your body weight and the specific condition being treated. This ensures that you receive the optimal amount of medication for your individual needs.
  • The infusion process will be closely monitored for any potential side effects or adverse reactions. Your comfort and safety are of utmost importance during the administration of ADVAMAB 400 INJECTION.
  • The duration of the infusion may vary depending on the dosage and your response to the medication. Your healthcare team will keep you informed throughout the process.
  • It is crucial to inform your doctor about any other medications you are currently taking, as well as any allergies or pre-existing medical conditions, before receiving ADVAMAB 400 INJECTION. This will help minimize the risk of any potential drug interactions or complications.

How to store ADVAMAB 400 INJECTION?Arrow

  • Keep ADVAMAB 400MG INJ away from the reach of children and pets.
  • Store ADVAMAB 400MG INJ in a refrigerator (2 - 8°C). Do not freeze.

Benefits of ADVAMAB 400 INJECTIONArrow

  • ADVAMAB 400 INJECTION is a specialized medication designed as a targeted therapy for the treatment of various advanced cancers. It operates through a precise mechanism, utilizing a recombinant humanized monoclonal antibody to selectively target a protein known as vascular endothelial growth factor A (VEGF-A). This protein is crucial in the formation of blood and lymph vessels that feed tumors.
  • By binding to VEGF-A, ADVAMAB 400 INJECTION disrupts its interaction with its receptors. This interruption is pivotal because it inhibits the process of angiogenesis, which is the formation of new blood vessels. Tumors rely on these blood vessels to receive the oxygen and nutrients necessary for their growth and proliferation.
  • Ultimately, ADVAMAB 400 INJECTION works to slow down the progression of cancer by cutting off the tumor's supply line. This targeted approach aims to control the growth and spread of cancerous cells, offering a therapeutic advantage in managing advanced stages of the disease.

How to use ADVAMAB 400 INJECTIONArrow

  • ADVAMAB 400 INJECTION will be administered to you by your doctor or nurse through an intravenous (IV) infusion. This means the medication will be delivered directly into your vein over a specific period.
  • The healthcare professional will carefully dilute ADVAMAB 400 INJECTION before administering it. This dilution process is essential to ensure the medication is delivered safely and effectively.
  • It is crucial that the infusion begins immediately after the dilution process. This is to maintain the stability and efficacy of the drug. Your doctor or nurse will monitor you closely during the infusion for any potential side effects or reactions.
  • The duration of the infusion will depend on various factors, including the specific condition being treated and your individual response to the medication. Your healthcare provider will determine the appropriate infusion rate and duration for you.
  • If you have any questions or concerns about the administration of ADVAMAB 400 INJECTION, please do not hesitate to ask your doctor or nurse. They are there to provide you with the information and support you need.

FAQs

Is ADVAMAB 400 INJECTION used as standalone treatment in cancers?Arrow

ADVAMAB 400 INJECTION is a recombinant monoclonal antibody that belongs to the immunotherapy class of cancer treatment. It can either be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate.

Is it safe for women to use ADVAMAB 400 INJECTION?Arrow

While for women with reproductive potential subjected to ADVAMAB 400 INJECTION, it is advised to discuss with your doctor regarding the effective birth control methods during the treatment. Also to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility.

Is it safe to undergo a surgery during the treatment with ADVAMAB 400 INJECTION?Arrow

ADVAMAB 400 INJECTION is associated with increased risk of bleeding complications and poor wound healing. Hence it is suggested to avoid planning for surgery and maintain an interval of 28days before or after surgery.

Do the side effects of ADVAMAB 400 INJECTION last for a chronic period?Arrow

All the side effects that are relatively caused by ADVAMAB 400 INJECTION occur until the drug concentration stays in the body. It is found that this medicine will be contained in our body for almost 4 months after the final dose.

How is ADVAMAB 400 INJECTION administered?Arrow

ADVAMAB 400 INJECTION is given intravenously through infusion and the amount of drug will be measured based on the patient’s body weight, height and age. The first dose will be administered for 90 minutes and if well tolerated the infusion time can be reduced to 30 minutes.

Can I take ADVAMAB 400 INJECTION if I am pregnant?Arrow

Inform your physician before starting your treatment with ADVAMAB 400 INJECTION in case, if you are pregnant or planning for pregnancy as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.

Does ADVAMAB 400 INJECTION interact with other drugs?Arrow

There are no known interactions of ADVAMAB 400 INJECTION with other drugs.

What should I tell my doctor before taking ADVAMAB 400 INJECTION?Arrow

It is vital to inform your physician before taking ADVAMAB 400 INJECTION if you have the following conditions: * Have conditions involving inflammation in the stomach (ulcer, colitis). * Experience allergic reactions to ADVAMAB 400 INJECTION or its ingredients. * Have recently undergone surgery as it is associated with the risk of bleeding. * Have diabetes, hypertension, or heart problems.

What is BEVACIZUMAB and how is it used for making ADVAMAB 400 INJECTION?Arrow

BEVACIZUMAB is a molecule used for making ADVAMAB 400 INJECTION.

What is ADVAMAB 400 INJECTION used for in Oncology?Arrow

ADVAMAB 400 INJECTION is used for treating various types of cancers in Oncology.

References

Book Icon

Roche Products Limited, Electronic Medicines Compendium (EMC).

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Roche Group, U.S FDA.

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Roche Group,Bevacizumab Injection, Indication.

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Ratings & Review

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Generic medicines at reasonable rates.

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Reviewed on 22-04-2024

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Should display more medical verities.

Ronak Ankola

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Reviewed on 25-07-2023

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(2/5)

Marketer / Manufacturer Details

ALKEM LABORATORIES LIMITED

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India

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