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Content Reviewed By:
Dr. Sanjay Mehta
, (MBBS)
Written By:
Ms. Kavita Desai
, (B.Pharm)
ISTAMET D XR 500MG TABLET, a medication for managing type 2 diabetes, may cause various side effects. Common ones include stomach upset, nausea, vomiting, diarrhea, abdominal pain, and a metallic taste in the mouth. Some individuals might experience headaches, stuffy nose, or a sore throat. Less common but serious side effects can include severe joint pain, pancreatitis (symptoms: severe stomach pain that may spread to your back, with or without vomiting), and allergic reactions like rash, hives, or swelling of the face, lips, tongue, or throat, leading to difficulty breathing or swallowing. A rare but severe side effect is lactic acidosis, characterized by unusual muscle pain, trouble breathing, stomach discomfort, dizziness, or feeling unusually cold. Low blood sugar (hypoglycemia) can occur, especially if this medicine is taken with other diabetes medications like insulin or sulfonylureas, presenting as dizziness, sweating, confusion, or shakiness. Always consult your doctor if you experience any concerning side effects.

Allergies
UnsafeDo not take Istamet D XR if you are allergic to Metformin, Sitagliptin, or any other ingredients.
It's an anti-diabetic medication used to control high blood sugar levels in adults with type 2 diabetes mellitus. It combines Sitagliptin and Metformin (extended-release).
The active ingredients are Sitagliptin and Metformin Hydrochloride (extended-release). The 500mg refers to Metformin.
Sitagliptin increases the amount of insulin released by the pancreas and reduces hormones that raise blood sugar. Metformin reduces glucose production in the liver, decreases glucose absorption from the intestines, and improves insulin sensitivity.
Take it exactly as prescribed by your doctor, usually once daily with a meal to reduce stomach upset. Swallow the tablet whole; do not crush, chew, or break it.
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
Common side effects include nausea, vomiting, diarrhea, stomach pain, headache, and upper respiratory tract infection. These are usually mild and temporary.
Serious but rare side effects include lactic acidosis (Metformin-related), pancreatitis, severe allergic reactions, and kidney problems. Seek immediate medical attention if you experience symptoms like severe stomach pain, unusual muscle pain, or difficulty breathing.
It should not be taken by patients with type 1 diabetes, diabetic ketoacidosis, severe kidney disease, liver disease, heart failure, or a history of serious allergic reaction to its ingredients.
Alcohol should be consumed with caution or avoided, as it can increase the risk of lactic acidosis (a serious side effect of Metformin) and also cause low blood sugar (hypoglycemia).
Store at room temperature (15-30°C or 59-86°F), away from moisture and light. Keep out of reach of children.
In case of an overdose, seek emergency medical attention immediately. Symptoms may include severe hypoglycemia or lactic acidosis.
No, ISTAMET D XR helps manage and control high blood sugar levels in type 2 diabetes but does not cure the condition. It needs to be taken regularly as part of a comprehensive management plan including diet and exercise.
Yes, other common brands containing this combination include Janumet XR, Zita-Met XR, and other strengths of Istamet. Always consult your doctor for suitable alternatives.
Regular exercise, a balanced diet (low in sugar and refined carbs), weight management, and monitoring blood sugar levels are crucial alongside medication for effective diabetes management.
It is generally not recommended during pregnancy or breastfeeding. Always consult your doctor, as they will weigh the potential benefits against risks and recommend alternatives if necessary.
Yes, regular monitoring of blood sugar levels is important to ensure the medication is working effectively and to prevent episodes of hypoglycemia or hyperglycemia. Your doctor will advise on the frequency of monitoring.
Metformin, one of the components, is often associated with stable weight or modest weight loss, not weight gain. Sitagliptin is generally weight-neutral. However, individual responses can vary.
Istamet D XR 500MG Tablet 7's is used for type 2 diabetes mellitus; also used in heart failure and chronic kidney disease in selected patients; first-line management of type 2 diabetes mellitus, usually alongside diet and exercise; and management of type 2 diabetes mellitus alongside diet and exercise, alone or with other antidiabetic medicines. Istamet D XR 500MG Tablet 7's contains Dapagliflozin 10 MG + Metformin Hydrochloride 500 MG Sustained Release + Sitagliptin 100 MG. Always use Istamet D XR 500MG Tablet 7's as advised by your doctor.
Istamet D XR 500MG Tablet 7's contains Dapagliflozin 10 MG + Metformin Hydrochloride 500 MG Sustained Release + Sitagliptin 100 MG. It is a SGLT2 inhibitor; biguanide antidiabetic; and DPP-4 inhibitor antidiabetic.
Commonly reported side effects of Istamet D XR 500MG Tablet 7's include genital fungal infections, urinary tract infections, increased urination, thirst, dehydration; diarrhoea, nausea, abdominal discomfort, metallic taste, loss of appetite — often improve with time or when taken with food; and headache, upper respiratory symptoms, nasal congestion, sore throat. Not everyone gets side effects. Tell your doctor or pharmacist if any effect persists or worries you.
Istamet D XR 500MG Tablet 7's is listed at Rs. 137.7 on Medkart. Prices can change — check the product page for the current price and pack size.
Risk of euglycaemic diabetic ketoacidosis — ketones may be raised with near-normal glucose; seek care for nausea, vomiting or abdominal pain; Rare but serious risk of lactic acidosis, particularly with kidney impairment, dehydration, acute illness or excess alcohol; and Rare reports of acute pancreatitis — stop and seek care for severe persistent abdominal pain. Tell your doctor about all other medicines you take before starting Istamet D XR 500MG Tablet 7's.
The dose of Istamet D XR 500MG Tablet 7's depends on your condition, age, weight and other medicines you take, so it must be decided by your doctor. Follow the dose and duration on your prescription and do not change it on your own.
A generic medicine is one with the same active composition as the branded product — for Istamet D XR 500MG Tablet 7's that is Dapagliflozin 10 MG + Metformin Hydrochloride 500 MG Sustained Release + Sitagliptin 100 MG. Medkart lists generic options by composition so you can compare. Ask your doctor or pharmacist before switching from Istamet D XR 500MG Tablet 7's.
Istamet D XR 500MG Tablet 7's contains Dapagliflozin 10 MG + Metformin Hydrochloride 500 MG Sustained Release + Sitagliptin 100 MG, a SGLT2 inhibitor; biguanide antidiabetic; and DPP-4 inhibitor antidiabetic. It is used for type 2 diabetes mellitus.
Yes. Istamet D XR 500MG Tablet 7's requires a valid doctor's prescription.
Istamet D XR 500MG Tablet 7's is manufactured by Sun Pharmaceutical Industries Ltd.
Istamet D XR 500MG Tablet 7's is supplied as a tablet and is taken by the oral route.
Istamet D XR 500MG Tablet 7's contains Dapagliflozin 10 MG + Metformin Hydrochloride 500 MG Sustained Release + Sitagliptin 100 MG. It is used for type 2 diabetes mellitus; also used in heart failure and chronic kidney disease in selected patients; first-line management of type 2 diabetes mellitus, usually alongside diet and exercise; and management of type 2 diabetes mellitus alongside diet and exercise, alone or with other antidiabetic medicines. The benefit you get depends on the condition your doctor prescribed Istamet D XR 500MG Tablet 7's for.
Whether Istamet D XR 500MG Tablet 7's can be taken daily, and for how long, depends on your condition and must be decided by your doctor. Do not start, extend or repeat a course of Istamet D XR 500MG Tablet 7's on your own.
The timing of Istamet D XR 500MG Tablet 7's depends on the dose your doctor prescribes and on the other medicines you take. Follow the timing on your prescription or ask your pharmacist.
No. Istamet D XR 500MG Tablet 7's is a prescription medicine and should only be taken on a doctor's advice.
Do not take Istamet D XR 500MG Tablet 7's during pregnancy or while breastfeeding without asking your doctor. Safety depends on the medicine, the stage of pregnancy and your own health.
Check with your doctor before drinking alcohol while taking Istamet D XR 500MG Tablet 7's. Alcohol can add to side effects such as drowsiness and can affect how some medicines work.
Store Istamet D XR 500MG Tablet 7's in its original pack, below 25°C unless the pack states otherwise, away from direct sunlight and moisture, and out of the reach of children. Do not use it after the expiry date on the pack.
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SUN PHARMACEUTICAL INDUSTRIES LTD
Country of Origin -
India
Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
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