SITAGLO M SR 100MG/500MG TABLET 15'S

How SITAGLO M SR 100MG/500MG TABLET 15'S Works

• SITAGLO M SR 100MG/500MG TABLET 15'S is a combination medicine designed to manage blood sugar levels in adults with type 2 diabetes mellitus. It combines two active ingredients, Sitagliptin and Metformin, each working through different mechanisms to achieve better glycemic control.
• Sitagliptin belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that inactivates incretin hormones. Incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine in response to food intake. These hormones stimulate insulin release from the pancreas and decrease glucagon secretion from the liver, both of which help lower blood sugar levels. Sitagliptin works by inhibiting DPP-4, thereby increasing the levels of active incretin hormones in the body. This enhancement of incretin activity leads to increased insulin release when blood sugar is high and decreased glucagon secretion when blood sugar is high, resulting in improved blood sugar control.
• Metformin, on the other hand, is a biguanide that primarily works by decreasing glucose production in the liver and improving insulin sensitivity in the body's tissues. Specifically, Metformin reduces hepatic glucose production by inhibiting gluconeogenesis (the production of glucose from non-carbohydrate sources) and glycogenolysis (the breakdown of glycogen into glucose). Additionally, it enhances insulin sensitivity in peripheral tissues, allowing cells to utilize glucose more effectively. Metformin may also slow down the absorption of glucose from the intestines.
• The combination of Sitagliptin and Metformin in SITAGLO M SR 100MG/500MG TABLET 15'S offers a dual approach to managing blood sugar. Sitagliptin enhances the body's own mechanisms to regulate blood sugar by increasing incretin hormone activity, while Metformin reduces glucose production and improves insulin sensitivity. This synergistic effect provides more effective blood sugar control than either drug alone. The 'SR' in the name stands for sustained release, which means Metformin is released slowly into the body, reducing the frequency of dosing and minimizing potential gastrointestinal side effects.
• Therefore, SITAGLO M SR 100MG/500MG TABLET 15'S works by addressing multiple pathways involved in blood sugar regulation, helping patients with type 2 diabetes achieve and maintain better glycemic control when used in conjunction with diet and exercise.

The following side effects may occur while taking SITAGLO M SR 100MG/500MG TABLET 15'S. Not all side effects are common, and some may be rare. **Common Side Effects:** * Nausea * Vomiting * Diarrhea * Abdominal pain * Loss of appetite * Metallic taste * Headache * Hypoglycemia (low blood sugar), especially when used with other diabetes medications **Uncommon Side Effects:** * Constipation * Flatulence * Upper respiratory tract infection * Skin rash or itching **Rare Side Effects:** * Lactic acidosis (symptoms may include feeling very weak, tired or uncomfortable; unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, feeling cold, especially in your arms and legs, feeling dizzy or lightheaded, or a slow or irregular heartbeat) * Pancreatitis (severe pain in the upper abdomen radiating to the back, with nausea and vomiting) * Severe allergic reactions (rash, itching, swelling of the face, lips, or tongue, difficulty breathing or swallowing) * Liver problems (yellowing of the skin or eyes, dark urine, pale stools, abdominal pain) * Vitamin B12 deficiency * Joint pain **Important Note:** This is not a complete list of side effects. If you experience any unusual symptoms while taking this medication, contact your doctor immediately.

• If you miss a dose of SITAGLO M SR 100MG/500MG TABLET 15'S, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

• Keep SITAGLO M SR 100/500MG TAB 1X15 away from the reach of children and pets.
• Store SITAGLO M SR 100/500MG TAB 1X15 at room temperature.

• Take SITAGLO M SR exactly as prescribed by your doctor. Do not alter the dosage or stop taking the medication without consulting your healthcare provider, as this could affect your blood sugar levels.
• Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect the extended-release mechanism and lead to inconsistent medication delivery.
• It's best to take SITAGLO M SR with food to minimize the risk of stomach upset. Consistent timing with meals can also help maintain steady blood sugar control throughout the day.
• Regularly monitor your blood sugar levels as directed by your doctor or diabetes educator. Keep a log of your readings to share with your healthcare team during appointments, which helps them assess the effectiveness of your treatment plan.
• Maintain a healthy lifestyle by following a balanced diet, engaging in regular physical activity, and managing stress. These lifestyle modifications can significantly enhance the effectiveness of SITAGLO M SR in controlling your blood sugar levels. Avoid excessive alcohol consumption.
• Be aware of the symptoms of low blood sugar (hypoglycemia), such as shakiness, sweating, dizziness, and confusion. Carry a source of fast-acting sugar with you, such as glucose tablets or juice, to treat low blood sugar promptly. Inform your family and friends about how to recognize and treat hypoglycemia.
• Inform your doctor about all other medications, supplements, and herbal products you are taking, as they may interact with SITAGLO M SR. Some medications can increase or decrease blood sugar levels, potentially requiring dosage adjustments.
• Store SITAGLO M SR at room temperature, away from moisture and heat. Keep the medication out of reach of children.
• Attend all scheduled appointments with your doctor and diabetes educator. Regular check-ups are essential for monitoring your progress, adjusting your treatment plan as needed, and addressing any concerns or side effects you may be experiencing.
• If you experience any persistent or bothersome side effects, such as nausea, diarrhea, or abdominal discomfort, consult your doctor. They can provide guidance on managing side effects or adjust your medication if necessary.

• SITAGLO M SR 100MG/500MG TABLET 15'S should be taken with food to decrease the chance of an upset stomach.
• Avoid excessive alcohol consumption while taking this medicine, as it may increase the risk of lactic acidosis (a serious metabolic complication).
• There are no specific food items that need to be avoided while taking SITAGLO M SR 100MG/500MG TABLET 15'S unless otherwise directed by your doctor.