LEUCORIN 50MG/5ML INJECTION
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LEUCORIN 50MG/5ML INJECTION
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LEUCORIN 50MG/5ML INJECTION

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LEUCORIN 50MG/5ML INJECTION

By SAMARTH LIFE SCIENCES PRIVATE LIMITED

MRP

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358.6

₹121

66.26 % OFF

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Product DetailsArrow

About LEUCORIN 50MG/5ML INJECTION

  • LEUCORIN 50MG/5ML INJECTION contains leucovorin calcium, a substance related to folic acid (a vitamin). It belongs to the class of medications known as folic acid analogs. This medication plays a vital role in protecting the body from the harmful effects of methotrexate, a powerful drug used in cancer treatment. It's also crucial for individuals who have accidentally overdosed on methotrexate or similar medications.
  • Furthermore, LEUCORIN 50MG/5ML INJECTION is used in combination with other anticancer drugs to combat colorectal cancer, which originates in the colon or rectum. Beyond cancer treatment, it addresses anemia stemming from folic acid deficiency, helping the body produce healthy red blood cells. This medication essentially helps rescue normal cells from the toxic effects of certain medications, ensuring that vital bodily functions continue.
  • Before using LEUCORIN 50MG/5ML INJECTION, inform your healthcare provider if you have any allergies to leucovorin calcium, calcium folinate, or any of the other ingredients in this medicine. It is also important to disclose if you have specific types of anemia, such as pernicious anemia or megaloblastic anemia due to vitamin B12 deficiency. Discuss any existing health conditions, particularly kidney, heart, or liver problems, with your doctor. Also, make them aware of any seizure medications you're currently taking.
  • Be vigilant for any signs of an allergic reaction, such as wheezing, difficulty breathing, skin rashes, itching, hives, or swelling of the lips, face, or tongue. Promptly report any such symptoms to your physician. This information ensures the safe and effective use of LEUCORIN 50MG/5ML INJECTION.

Uses of LEUCORIN 50MG/5ML INJECTION

  • Addressing Methotrexate Overdose and Toxicity: Managing the risks and complications associated with excessive methotrexate levels in the body.
  • Preventing the Harmful Effects of Methotrexate or Similar Medications: Strategies to minimize side effects and protect against toxicity from methotrexate and related drugs.
  • Colorectal Cancer: Treatment of cancer affecting the colon and rectum
  • Anemia: Management of conditions characterized by a deficiency of red blood cells or hemoglobin in the blood.

Side Effects of LEUCORIN 50MG/5ML INJECTIONArrow

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

  • Diarrhea
  • Nausea
  • Vomiting
  • Inflammmed and sore mouth
  • Tiredness
  • Allergic reactions

Safety Advice for LEUCORIN 50MG/5ML INJECTIONArrow

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Pregnancy

CONSULT YOUR DOCTOR

There is a limited number of studies on the safety of LEUCORIN 50MG/5ML INJECTION during pregnancy, and it is unknown whether the medicine can be given during pregnancy. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.

Dosage of LEUCORIN 50MG/5ML INJECTIONArrow

  • A qualified healthcare professional, such as a physician or nurse specializing in cancer chemotherapy, will administer LEUCORIN 50MG/5ML INJECTION. This ensures the medication is given safely and effectively.
  • The precise dosage and duration of your treatment will be determined by your doctor. This decision is based on a comprehensive assessment of your individual condition, including the specific type and severity of your disease, your overall health status, and other relevant factors that may influence how you respond to the medication. Your doctor will carefully consider all these aspects to personalize your treatment plan.
  • LEUCORIN 50MG/5ML INJECTION is administered either intravenously (directly into a vein) or intramuscularly (directly into a muscle). The method of administration depends on your specific medical condition and the doctor's judgment regarding the most appropriate and effective route for you. They will explain the reasons behind their choice and ensure you are comfortable with the process.
  • It is important to adhere to the schedule of appointments for your injections. Regular visits will ensure optimal care.
  • Any concerns or discomforts during and after the treatment should be reported immediately to your doctor. This will help manage the side effects efficiently.

How to store LEUCORIN 50MG/5ML INJECTION?Arrow

  • Keep LEUCORIN 50MG INJ 5ML away from the reach of children and pets.
  • Store LEUCORIN 50MG INJ 5ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of LEUCORIN 50MG/5ML INJECTIONArrow

  • LEUCORIN 50MG/5ML INJECTION serves as a vital rescue medication, effectively mitigating the adverse effects of folic acid antagonists like methotrexate. These antagonists, crucial in treating certain cancers and autoimmune diseases, work by inhibiting dihydrofolate reductase, an enzyme essential for cell growth and replication. LEUCORIN 50MG/5ML INJECTION replenishes the reduced folates, bypassing the blocked enzyme and restoring normal cellular function. This rescue mechanism is particularly important in preventing severe side effects such as bone marrow suppression, mucositis (inflammation of the mucous membranes), and gastrointestinal problems associated with high-dose methotrexate therapy.
  • Furthermore, LEUCORIN 50MG/5ML INJECTION plays a crucial role in treating megaloblastic anemia, a condition characterized by abnormally large and immature red blood cells. This type of anemia often arises from a deficiency in folic acid or vitamin B12, both of which are essential for DNA synthesis and red blood cell maturation. By providing a readily available source of folic acid, LEUCORIN 50MG/5ML INJECTION helps to correct the underlying deficiency, promoting the production of healthy red blood cells and alleviating the symptoms of anemia, such as fatigue, weakness, and shortness of breath.
  • In the treatment of colorectal cancer, LEUCORIN 50MG/5ML INJECTION is frequently used in combination with 5-fluorouracil (5-FU). While 5-FU inhibits thymidylate synthase, an enzyme critical for DNA synthesis, LEUCORIN 50MG/5ML INJECTION enhances the cytotoxic effects of 5-FU. This synergistic action increases the effectiveness of chemotherapy, leading to improved tumor response rates and overall survival in patients with colorectal cancer. The administration of LEUCORIN 50MG/5ML INJECTION alongside 5-FU requires careful monitoring to optimize the therapeutic benefits while minimizing potential toxicities.
  • LEUCORIN 50MG/5ML INJECTION essentially counteracts the therapeutic effects of folic acid antagonists such as methotrexate and similar medications by inhibiting the dihydrofolate reductase enzyme. It treats anemia by supplying the folic acid needed for red blood cell formation. It treats colorectal cancer by enhancing the therapeutic effects of another anticancer medication called 5-fluorouracil.

How to use LEUCORIN 50MG/5ML INJECTIONArrow

  • LEUCORIN 50MG/5ML INJECTION will be administered by a trained physician or nurse experienced in cancer chemotherapy. The dosage and duration of your treatment will be determined by your doctor, taking into account your specific condition, its severity, and other relevant factors. This ensures the treatment is tailored to your individual needs for the best possible outcome.
  • The method of administration, whether intravenously (into a vein) or intramuscularly (into a muscle), will also be determined by your doctor based on your specific disease condition. Intravenous administration allows the medication to enter your bloodstream directly for immediate effect, while intramuscular injection provides a slower, more sustained release.
  • It is crucial to adhere to the prescribed treatment schedule and dosage provided by your healthcare provider. Do not attempt to self-administer LEUCORIN 50MG/5ML INJECTION. Consistent communication with your doctor regarding any side effects or concerns is essential for a successful treatment journey. Your doctor may adjust the dosage or treatment plan as needed based on your response to the medication and any side effects you may experience. Regular monitoring is a vital part of ensuring your safety and the effectiveness of the therapy.

FAQs

Why is LEUCORIN 50MG/5ML INJECTION given 24 hours after methotrexate?Arrow

LEUCORIN 50MG/5ML INJECTION is usually administered 24 hours after methotrexate so that it does not interfere with the therapeutic effect of methotrexate. It can also be used in methotrexate overdose; it should be administered as soon as possible.

Can LEUCORIN 50MG/5ML INJECTION cause swelling?Arrow

LEUCORIN 50MG/5ML INJECTION may cause allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.

Can LEUCORIN 50MG/5ML INJECTION cause seizures?Arrow

There is no evidence that LEUCORIN 50MG/5ML INJECTION cause seizures. But the medicine can affect the effect of seizure medication when administered concurrently. Inform your physician about all your medicines, including over-the-counter medications.

How long does it take for LEUCORIN 50MG/5ML INJECTION to work?Arrow

LEUCORIN 50MG/5ML INJECTION starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with LEUCORIN 50MG/5ML INJECTION?Arrow

A healthcare professional will monitor you during the treatment with this medicine. Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor the alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

NULL interaction of LEUCORIN 50MG/5ML INJECTION with other drungsArrow

There are no known interactions of LEUCORIN 50MG/5ML INJECTION with other drugs.

What advice should I follow while taking LEUCORIN 50MG/5ML INJECTION?Arrow

If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking these medicinal products. Inform your doctor if you have vomited immediately after receiving the injection. If you accidentally take too much LEUCORIN 50MG/5ML INJECTION. contact your doctor and seek medical advice immediately. Do not stop taking this medicine unless your doctor tells you to. Your doctor will regularly do lab tests to check the effectiveness of the medicine.

Which molecule/combination is used for making LEUCORIN 50MG/5ML INJECTION?Arrow

LEUCOVORIN CALCIUM is the molecule/combination used for making LEUCORIN 50MG/5ML INJECTION.

How does LEUCORIN 50MG/5ML INJECTION help in Oncology?Arrow

LEUCORIN 50MG/5ML INJECTION is used to help reduce or prevent the side effects of some cancer drugs.

When is LEUCORIN 50MG/5ML INJECTION used in Oncology?Arrow

LEUCORIN 50MG/5ML INJECTION is used after high doses of folic acid antagonists such as methotrexate to protect normal cells.

References

Book Icon

Calcium Folinate 10 mg/ml Injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. 2020

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HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet].

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Marketer / Manufacturer Details

SAMARTH LIFE SCIENCES PRIVATE LIMITED

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India

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LEUCORIN 50MG/5ML INJECTION

LEUCORIN 50MG/5ML INJECTION

MRP

₹

358.6

₹121

66.26 % OFF

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