SHILSTINE 50 INJECTION
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SHILSTINE 50 INJECTION
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SHILSTINE 50 INJECTION

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SHILSTINE 50 INJECTION

By SHILPA MEDICARE LTD

MRP

₹

265

₹100

62.26 % OFF

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Product DetailsArrow

Content Reviewed By:

Dr. Neha Patel

, (MBBS)

Written By:

Mr. Ankit Jain

, (B.Pharm)

About SHILSTINE 50 INJECTION

  • SHILSTINE 50 INJECTION contains leucovorin calcium, a substance closely related to folic acid, a vital vitamin. As a folic acid analog, it plays a crucial role in mitigating the adverse effects of methotrexate, a medication employed in the treatment of specific cancers. It serves as an antidote for individuals who have inadvertently overdosed on methotrexate or similar drugs. Furthermore, it finds application alongside other anticancer agents in the management of colorectal cancer, which originates in the colon or rectum. SHILSTINE 50 INJECTION is also indicated for addressing anemia stemming from folic acid deficiency.
  • Before commencing treatment with SHILSTINE 50 INJECTION, it's crucial to inform your healthcare provider about any existing allergies to leucovorin calcium, calcium folinate, or any other components of the medication. This medication is contraindicated in individuals with specific types of anemia, such as pernicious anemia or megaloblastic anemia, characterized by vitamin B12 deficiency. Transparency regarding your medical history, including any anemia, kidney, heart, or liver conditions, is paramount. Additionally, disclose any concurrent use of seizure medications. Promptly report any symptoms indicative of an allergic reaction, such as wheezing, breathing difficulties, skin rash, itching, hives, or swelling of the lips, face, or tongue.
  • SHILSTINE 50 INJECTION can be a valuable component of cancer treatment and in managing certain types of anemia, but is important to communicate openly with your doctor about your medical history and any concerns you may have. This ensures you receive the best and safest possible care. Remember to discuss any medications you're taking and any existing health conditions to prevent potential interactions or complications. Regular check-ups and adherence to your doctor's instructions are essential for a successful treatment outcome.

Uses of SHILSTINE 50 INJECTION

  • Addressing methotrexate overdose and toxicity issues.
  • Preventing the harmful effects of methotrexate or similar medications, reducing potential risks.
  • Managing colorectal cancer treatment and care.
  • Providing support in cases of anemia.

Side Effects of SHILSTINE 50 INJECTIONArrow

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

  • Diarrhea
  • Nausea
  • Vomiting
  • Inflamed and sore mouth
  • Tiredness
  • Allergic reactions

Safety Advice for SHILSTINE 50 INJECTIONArrow

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Pregnancy

CONSULT YOUR DOCTOR

There is a limited number of studies on the safety of SHILSTINE 50 INJECTION during pregnancy, and it is unknown whether the medicine can be given during pregnancy. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.

Dosage of SHILSTINE 50 INJECTIONArrow

  • A qualified healthcare professional, such as a physician or nurse specializing in cancer chemotherapy, will administer SHILSTINE 50 INJECTION. This ensures the drug is given safely and effectively under expert supervision.
  • The precise dosage and duration of your SHILSTINE 50 INJECTION treatment will be determined by your doctor. They will carefully consider several factors, including the specific type and stage of your cancer, the severity of your condition, your overall health, and your response to the medication. This personalized approach is crucial for optimizing the treatment's effectiveness and minimizing potential side effects.
  • SHILSTINE 50 INJECTION is administered either intravenously (directly into a vein) or intramuscularly (directly into a muscle). The method of administration will depend on your individual disease condition and the doctor's judgment. Intravenous administration allows the drug to enter the bloodstream quickly, while intramuscular administration allows for a slower, more sustained release. Your doctor will explain the chosen method and the reasons behind it.
  • It is important to adhere to the prescribed treatment schedule and attend all scheduled appointments. If you have any concerns or experience any unusual side effects, it is essential to inform your doctor immediately. They can provide guidance and make any necessary adjustments to your treatment plan.

How to store SHILSTINE 50 INJECTION?Arrow

  • Keep SHILSTINE 50MG INJ 5ML away from the reach of children and pets.
  • Store SHILSTINE 50MG INJ 5ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of SHILSTINE 50 INJECTIONArrow

  • SHILSTINE 50 INJECTION works by directly interfering with how certain medications, specifically folic acid antagonists like methotrexate, function in the body. It does this by blocking an enzyme known as dihydrofolate reductase. This enzyme is crucial for the activation of folic acid, which is essential for various bodily processes, including cell growth and DNA synthesis. By inhibiting this enzyme, SHILSTINE 50 INJECTION effectively reduces the impact of drugs that rely on this pathway to exert their therapeutic effects.
  • Furthermore, SHILSTINE 50 INJECTION plays a vital role in treating anemia, particularly when it's caused by a deficiency in folic acid. Folic acid is a necessary building block for the production of healthy red blood cells. SHILSTINE 50 INJECTION replenishes the body's supply of folic acid, ensuring that red blood cell formation can proceed normally, thereby alleviating the symptoms of anemia and improving overall health.
  • In the treatment of colorectal cancer, SHILSTINE 50 INJECTION is often used in conjunction with another anticancer medication called 5-fluorouracil. SHILSTINE 50 INJECTION can enhance the effectiveness of 5-fluorouracil, leading to improved outcomes for patients undergoing chemotherapy. This combination therapy is a common approach in managing colorectal cancer and aims to maximize the therapeutic benefits while minimizing potential side effects.

How to use SHILSTINE 50 INJECTIONArrow

  • SHILSTINE 50 INJECTION will be administered to you by a trained healthcare professional, such as a physician or nurse experienced in cancer chemotherapy. They will carefully manage the administration process to ensure your safety and the effectiveness of the treatment.
  • Your doctor will determine the precise dosage and the length of your treatment plan. This decision is based on a comprehensive evaluation of your specific disease, its severity, and other relevant factors, such as your overall health and any other medications you may be taking. It's crucial to follow your doctor's instructions closely and attend all scheduled appointments to optimize the benefits of the treatment.
  • The medication is administered either intravenously (directly into your vein) or intramuscularly (directly into your muscle), depending on the specifics of your condition and the medication's properties. The healthcare provider will select the most appropriate method to ensure the medication is delivered effectively and safely. They will also monitor you closely for any potential side effects during and after the administration.
  • If you have any questions or concerns about the administration of SHILSTINE 50 INJECTION, don't hesitate to ask your doctor or nurse. They are there to provide you with the information and support you need throughout your treatment journey.

Top Substitutes for SHILSTINE 50 INJECTION

MedicineManufacturerPack SizeMRPMedkart PriceSavings (%)
ES LC 50MG INJ 5MLESPERER BIORESEARCH53256480.31
LUKSTER 50MG INJ 5MLMETTA LIFE SCIENCES PVT LTD53107177.1
ONCOVORIN 50MG INJ 5MLBANGALORE PHARMACEUTICAL & RESEARCH LABORATORY (P) LTD535810770.11
ADCOV 50MG INJ 5MLADLEY FORMULATIONS PRIVATE LIMITED5234.3811152.64
LEUCORIN 50MG INJ 5MLSAMARTH LIFE SCIENCES PRIVATE LIMITED5358.612166.26
LUCALJECT 50MG INJAEGIS133615055.36
UNIFOLIN 50MG INJ 5MLUNITED BIOTECH PVT LTD5312.917743.43
LEUCOKAST 50MG INJ 5MLAPRAZER HEALTHCARE PVT LTD535817950
LEUGET 50MG INJ 5MLGLS PHARMA LIMITED531018739.68
LEUCOVORIN CALCIUM 50MG INJ 5MLFRESENIUS KABI INDIA PVT LTD5358.619844.79
BIOVORIN 50MG INJ 5MLZYDUS LIFESCIENCES LIMITED547424049.37
RECOVORIN 50MG INJ 5MLCADILA PHARMACEUTICALS PRIVATE LIMITED5291247.3515
LEUTERO 50MG INJ 5MLHETERO HEALTHCARE LTD52757772

FAQs

Why is SHILSTINE 50 INJECTION given 24 hours after methotrexate?Arrow

SHILSTINE 50 INJECTION is usually administered 24 hours after methotrexate so that it does not interfere with the therapeutic effect of methotrexate. It can also be used in methotrexate overdose; it should be administered as soon as possible.

Can SHILSTINE 50 INJECTION cause swelling?Arrow

SHILSTINE 50 INJECTION may cause allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.

Can SHILSTINE 50 INJECTION cause seizures?Arrow

There is no evidence that SHILSTINE 50 INJECTION cause seizures. But the medicine can affect the effect of seizure medication when administered concurrently. Inform your physician about all your medicines, including over-the-counter medications.

How long does it take for Shilstine 50mg Injection to work?Arrow

SHILSTINE 50 INJECTION starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Shilstine 50mg Injection?Arrow

A healthcare professional will monitor you during the treatment with this medicine. Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor the alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

NULL interaction of SHILSTINE 50 INJECTION with other drungsArrow

NULL

If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking these medicinal products. Inform your doctor if you have vomited immediately after receiving the injection. If you accidentally take too much Shilstine 50mg Injection. contact your doctor and seek medical advice immediately. Do not stop taking this medicine unless your doctor tells you to. Your doctor will regularly do lab tests to check the effectiveness of the medicine. is an advice related to SHILSTINE 50 INJECTIONArrow

If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking these medicinal products. Inform your doctor if you have vomited immediately after receiving the injection. If you accidentally take too much SHILSTINE 50 INJECTION. contact your doctor and seek medical advice immediately. Do not stop taking this medicine unless your doctor tells you to. Your doctor will regularly do lab tests to check the effectiveness of the medicine.

LEUCOVORIN CALCIUM is molecule/combination used for making SHILSTINE 50 INJECTION. Create FAQ for thisArrow

LEUCOVORIN CALCIUM is a molecule/combination used for making SHILSTINE 50 INJECTION.

Oncology are ailments/disease/conditions for which SHILSTINE 50 INJECTION is presecribed. Create 2-4 FAQs using this data. If {Oncology} contains word "Others" dont create.Arrow

SHILSTINE 50 INJECTION is primarily used in Oncology, which relates to the treatment of cancer.

References

Book Icon

Calcium Folinate 10 mg/ml Injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. 2020.

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HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet].

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Ratings & Review

Excellent 👍👍👍

ashok badhala

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Reviewed on 26-11-2022

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(5/5)

Genuine products

monalisha satapathy

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Reviewed on 05-08-2023

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(5/5)

Good Service and Price

Pranit Parmar

•

Reviewed on 22-11-2022

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(5/5)

Best place to get your medicines, humble and helping people, most reasonable rates.

Jatin Dave

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Reviewed on 08-07-2023

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(5/5)

Good service , great discount, I am regular customer

Gohil Aadityaraj

•

Reviewed on 27-07-2023

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(5/5)


Marketer / Manufacturer Details

SHILPA MEDICARE LTD

Country of Origin -

India

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62.26 % OFF

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Disclaimer

Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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