LEUCOVORIN CALCIUM 50MG/5ML INJECTION
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LEUCOVORIN CALCIUM 50MG/5ML INJECTION
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LEUCOVORIN CALCIUM 50MG/5ML INJECTION

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LEUCOVORIN CALCIUM 50MG/5ML INJECTION

By FRESENIUS KABI INDIA PVT LTD

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330.94

₹198

40.17 % OFF

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Product DetailsArrow

About LEUCOVORIN CALCIUM 50MG/5ML INJECTION

  • LEUCOVORIN CALCIUM 50MG/5ML INJECTION contains leucovorin calcium, a substance closely related to folic acid, a vital vitamin. It belongs to a class of medications known as folic acid analogs. This medication plays a crucial role in mitigating the adverse effects of methotrexate, a powerful drug used in the treatment of specific cancers. It is also administered to individuals who have experienced an accidental overdose of methotrexate or similar medications. Furthermore, LEUCOVORIN CALCIUM 50MG/5ML INJECTION is used in conjunction with other anticancer drugs in the treatment of colorectal cancer, which originates in the colon or rectum. Beyond its role in cancer therapy, it can also address anemia resulting from folic acid deficiency.
  • It's important to understand when LEUCOVORIN CALCIUM 50MG/5ML INJECTION is not appropriate. Avoid this medication if you have a known allergy to leucovorin calcium, calcium folinate, or any of the other ingredients in the formulation. It is also contraindicated in certain types of anemia, specifically pernicious anemia or megaloblastic anemia, where there is a deficiency in vitamin B12. Before commencing treatment, inform your doctor about any pre-existing medical conditions, including anemia, kidney problems, heart issues, or liver disorders. Also, disclose any medications you are currently taking, especially those used to manage seizures. Be vigilant for any signs of an allergic reaction, such as wheezing, difficulty breathing, skin rash, itching, hives, or swelling of the lips, face, or tongue, and promptly report them to your physician.
  • LEUCOVORIN CALCIUM 50MG/5ML INJECTION is often administered following high-dose methotrexate therapy. Methotrexate, while effective against cancer cells, can also harm healthy cells. Leucovorin acts as a rescue medication, selectively protecting normal cells from the toxic effects of methotrexate. By providing a source of folate, leucovorin allows normal cells to continue essential metabolic processes that would otherwise be blocked by methotrexate. This allows for higher doses of methotrexate to be used, improving cancer treatment outcomes while minimizing damage to the patient's healthy tissues. The dosage and timing of leucovorin administration are critical and must be carefully determined by the physician based on the specific methotrexate protocol being used and the patient's individual characteristics and kidney function.

Uses of LEUCOVORIN CALCIUM 50MG/5ML INJECTION

  • Managing Methotrexate Overdose and Toxicity: Addressing the dangers of excessive methotrexate levels and mitigating their toxic effects on the body.
  • Preventing the Harmful Effects of Methotrexate or Similar Medications: Taking steps to minimize potential side effects and adverse reactions associated with methotrexate or drugs with comparable mechanisms.
  • Colorectal Cancer: Addressing cancer affecting the colon and rectum, focusing on treatment strategies and supportive care.
  • Anemia: Managing conditions characterized by a deficiency of red blood cells or hemoglobin in the blood, leading to reduced oxygen transport.

Side Effects of LEUCOVORIN CALCIUM 50MG/5ML INJECTIONArrow

Side effects are unwanted symptoms caused by medicines, though not everyone experiences them. With LEUCOVORIN CALCIUM 50MG/5ML INJECTION, common side effects include diarrhea, nausea, vomiting, an inflamed and sore mouth, and tiredness. Serious side effects may include allergic reactions.

  • Diarrhea
  • Nausea
  • Vomiting
  • Inflammmed and sore mouth
  • Tiredness
  • Allergic reactions

Safety Advice for LEUCOVORIN CALCIUM 50MG/5ML INJECTIONArrow

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Pregnancy

CONSULT YOUR DOCTOR

There is a limited number of studies on the safety of LEUCOVORIN CALCIUM 50MG/5ML INJECTION during pregnancy, and it is unknown whether the medicine can be given during pregnancy. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.

Dosage of LEUCOVORIN CALCIUM 50MG/5ML INJECTIONArrow

  • LEUCOVORIN CALCIUM 50MG/5ML INJECTION will be administered by a trained physician or nurse experienced in cancer chemotherapy. The dosage and duration of treatment will be determined by your doctor, taking into account your specific disease, its severity, and other individual health factors.
  • This medication is typically administered either intravenously (directly into your vein) or intramuscularly (directly into your muscle), depending on your specific medical condition and the treatment protocol. The intravenous route allows for a quicker and more direct absorption of the medication into your bloodstream.
  • Your doctor will closely monitor your response to the treatment and may adjust the dosage or duration as needed to achieve the best possible outcome. It's crucial to follow your doctor's instructions precisely and attend all scheduled appointments. Regular monitoring and adjustments are key to ensuring the effectiveness and safety of your treatment with LEUCOVORIN CALCIUM 50MG/5ML INJECTION.

How to store LEUCOVORIN CALCIUM 50MG/5ML INJECTION?Arrow

  • Keep LEUCOVORIN CALCIUM 50MG INJ 5ML away from the reach of children and pets.
  • Store LEUCOVORIN CALCIUM 50MG INJ 5ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of LEUCOVORIN CALCIUM 50MG/5ML INJECTIONArrow

  • LEUCOVORIN CALCIUM 50MG/5ML INJECTION serves as a vital countermeasure against the effects of folic acid antagonists, including methotrexate. These antagonists work by inhibiting the dihydrofolate reductase enzyme, an essential component in the body's utilization of folic acid. By providing an alternative source of reduced folates, leucovorin bypasses this enzymatic block, allowing crucial metabolic processes to continue.
  • Furthermore, LEUCOVORIN CALCIUM 50MG/5ML INJECTION plays a significant role in treating certain types of anemia. Anemia often arises from a deficiency in folic acid, which is crucial for the production of healthy red blood cells. By supplementing the body with the necessary folic acid derivatives, this injection supports the formation of red blood cells, alleviating the symptoms and effects of anemia.
  • In the realm of cancer treatment, LEUCOVORIN CALCIUM 50MG/5ML INJECTION is frequently used in conjunction with 5-fluorouracil, a chemotherapy medication. Leucovorin enhances the cytotoxic (cell-killing) effects of 5-fluorouracil on cancer cells. This synergistic action makes the combination more effective in treating colorectal cancer and potentially other malignancies, leading to improved patient outcomes. The drug essentially boosts the 5-fluorouracil activity.
  • Beyond these primary applications, LEUCOVORIN CALCIUM 50MG/5ML INJECTION may also be used in other clinical scenarios where folic acid deficiencies or the need to counteract folic acid antagonists arise. Its versatile nature makes it a valuable tool in various medical settings.

How to use LEUCOVORIN CALCIUM 50MG/5ML INJECTIONArrow

  • LEUCOVORIN CALCIUM 50MG/5ML INJECTION will be administered to you by a qualified physician or nurse who specializes in cancer chemotherapy. The dosage and length of treatment will be determined by your doctor, taking into account the specifics of your condition, its severity, and other relevant health factors. The drug can be administered either intravenously, directly into your vein, or intramuscularly, into your muscle tissue. The method of administration will be decided based on your individual medical needs and the nature of your disease.
  • Prior to each treatment session, your doctor will likely conduct blood tests and other evaluations to monitor your body's response to the medication and make sure it is safe for you to continue receiving it. It's essential to inform your doctor about any other medications you're taking, including prescription, over-the-counter, and herbal remedies, as well as any allergies or pre-existing medical conditions you may have. This information is crucial for your doctor to determine the most appropriate and safest course of treatment for you.
  • It is also important to adhere to the appointment schedule established by your healthcare provider and to promptly report any unusual side effects or concerns you may experience during or after the treatment sessions. Communication is key to ensuring the effectiveness and safety of your treatment.

FAQs

Why is LEUCOVORIN CALCIUM 50MG/5ML INJECTION given 24 hours after methotrexate?Arrow

LEUCOVORIN CALCIUM 50MG/5ML INJECTION is usually administered 24 hours after methotrexate so that it does not interfere with the therapeutic effect of methotrexate. It can also be used in methotrexate overdose; it should be administered as soon as possible.

Can LEUCOVORIN CALCIUM 50MG/5ML INJECTION cause swelling?Arrow

LEUCOVORIN CALCIUM 50MG/5ML INJECTION may cause allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.

Can LEUCOVORIN CALCIUM 50MG/5ML INJECTION cause seizures?Arrow

There is no evidence that LEUCOVORIN CALCIUM 50MG/5ML INJECTION cause seizures. But the medicine can affect the effect of seizure medication when administered concurrently. Inform your physician about all your medicines, including over-the-counter medications.

How long does it take for LEUCOVORIN CALCIUM 50MG/5ML INJECTION to work?Arrow

LEUCOVORIN CALCIUM 50MG/5ML INJECTION starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with LEUCOVORIN CALCIUM 50MG/5ML INJECTION?Arrow

A healthcare professional will monitor you during the treatment with this medicine. Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor the alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

Does LEUCOVORIN CALCIUM 50MG/5ML INJECTION interact with other drugs?Arrow

There are no known interactions of LEUCOVORIN CALCIUM 50MG/5ML INJECTION with other drugs.

What advice should I follow while taking LEUCOVORIN CALCIUM 50MG/5ML INJECTION?Arrow

If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking these medicinal products. Inform your doctor if you have vomited immediately after receiving the injection. If you accidentally take too much LEUCOVORIN CALCIUM 50MG/5ML INJECTION, contact your doctor and seek medical advice immediately. Do not stop taking this medicine unless your doctor tells you to. Your doctor will regularly do lab tests to check the effectiveness of the medicine.

What is Leucovorin Calcium?Arrow

Leucovorin Calcium is a molecule/combination used for making LEUCOVORIN CALCIUM 50MG/5ML INJECTION.

For what ailments/diseases/conditions is LEUCOVORIN CALCIUM 50MG/5ML INJECTION prescribed?Arrow

LEUCOVORIN CALCIUM 50MG/5ML INJECTION is prescribed for {Oncology} ailments/diseases/conditions.

References

Book Icon

Calcium Folinate 10 mg/ml Injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. 2020

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HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet].

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Awesome experience every time i get medicine on time and they have delivery on time also staff are very cooperative and knowledgeable

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Reviewed on 22-06-2023

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Good. Provides medicines at reasonable rates.

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Good discount available on Generic medicines and supportive staff. Thank you.

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amit sharma

Reviewed on 17-07-2023

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(5/5)


Marketer / Manufacturer Details

FRESENIUS KABI INDIA PVT LTD

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LEUCOVORIN CALCIUM 50MG/5ML INJECTION

LEUCOVORIN CALCIUM 50MG/5ML INJECTION

MRP

330.94

₹198

40.17 % OFF

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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