ACOZACIT INJECTION
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ACOZACIT INJECTION
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ACOZACIT INJECTION

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ACOZACIT INJECTION

By ACCORD PHARMA

MRP

2545

₹2545

10

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Product DetailsArrow

About ACOZACIT INJECTION

  • ACOZACIT INJECTION is a medication specifically designed for adult patients diagnosed with Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) who are not suitable candidates for stem cell transplantation. This injection offers a therapeutic option for individuals facing these challenging conditions.
  • Myelodysplastic Syndromes (MDS) are a group of disorders where the bone marrow malfunctions, leading to insufficient production of healthy blood cells. This deficiency can result in anemia, increased risk of infections, and bleeding problems. ACOZACIT INJECTION helps to improve blood cell production in these patients.
  • Acute Myeloid Leukemia (AML) is a form of cancer affecting the bone marrow and blood. It is characterized by the rapid proliferation of abnormal, immature blood cells that disrupt normal blood cell production. ACOZACIT INJECTION targets these abnormal cells, aiming to slow down their growth and improve overall blood counts.
  • ACOZACIT INJECTION works by interfering with the growth of cancer cells and promoting the development of healthy blood cells. It is administered under the supervision of a healthcare professional, who will determine the appropriate dosage and treatment schedule based on individual patient needs and medical history.
  • Patients receiving ACOZACIT INJECTION should be closely monitored for potential side effects, and any concerns should be promptly reported to their healthcare provider. Regular blood tests and check-ups are crucial to assess treatment response and manage any adverse reactions effectively. This medication offers a crucial treatment option for patients who may have limited alternatives.

Uses of ACOZACIT INJECTION

  • Treatment of Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Hematopoietic stem cell transplant, focusing on supportive care and symptom management alongside specific AML-directed therapies.
  • Management of Intermediate-2 and High-risk Myelodysplastic Syndrome (MDS) aiming to improve hematopoiesis and reduce the risk of progression to acute leukemia, utilizing treatment strategies based on individual patient risk stratification.

Side Effects of ACOZACIT INJECTIONArrow

Side effects are unwanted symptoms caused by medicines, though not everyone experiences them. Seek immediate medical attention for serious side effects such as unexpected bleeding (blood in stool/urine), fever, pneumonia (chest pain/breathlessness), allergic reactions (swelling, itching, rashes), seizures, loss of consciousness, severe headache, or bleeding in the brain, and frequent painful urination. Common side effects include disturbances in blood count, nausea, vomiting, diarrhea, constipation, tiredness, injection site reactions, decreased appetite, dizziness, extremity pain, joint pain, stomach pain, headache, sore nose/throat, and rashes/bruising.

  • Unexpected bleeding, with blood in stool and urine
  • Fever
  • Pneumonia, characterized by chest pain or breathlessness.
  • Allergic reaction with symptoms of swelling of lips, itching or rashes.
  • Seizures, loss of consciousness, severe headache or bleeding in the brain
  • Frequent urination with pain or burning sensation
  • Disturbances in the blood count (RBC, WBC, Platelets)
  • Nausea, vomiting, diarrhea
  • Constipation
  • Tiredness
  • Skin reaction like redness and pain at the site of injection
  • Decreased appetite
  • Dizziness
  • Pain in extremities
  • Joint pain
  • Stomach pain
  • Headache
  • Sore nose and throat
  • Rashes and bruising

Safety Advice for ACOZACIT INJECTIONArrow

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Pregnancy

UNSAFE

ACOZACIT INJECTION could be harmful to the unborn fetus. Inform your physician if you are pregnant or planning to get pregnant.

Dosage of ACOZACIT INJECTIONArrow

  • ACOZACIT INJECTION should only be administered under the direct supervision of a qualified physician. Self-administration is strongly discouraged, as the dosage and administration technique require specific medical expertise.
  • The precise dosage of ACOZACIT INJECTION will be determined by your physician, taking into account several individual factors. These include your height, weight, overall health condition, and the specific medical indication for which you are receiving the injection.
  • ACOZACIT INJECTION is typically administered via subcutaneous injection, meaning it is injected under the skin. Common injection sites include the thigh, stomach (abdomen), or upper arm. Your physician or a trained healthcare professional will select the most appropriate injection site and administer the injection using proper sterile techniques.
  • It's crucial to adhere to the prescribed dosage and injection schedule provided by your physician. Any deviations from the recommended regimen could potentially affect the efficacy of the medication or increase the risk of adverse effects. If you have any concerns or questions regarding your dosage or administration, consult your physician immediately.

How to store ACOZACIT INJECTION?Arrow

  • Keep ACOZACIT 100MG INJ away from the reach of children and pets.
  • Store ACOZACIT 100MG INJ at room temperature.

Benefits of ACOZACIT INJECTIONArrow

  • In Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML), the uncontrolled growth of tumor cells stems from a process called transcriptional repression. This repression occurs due to the hypermethylation of DNA, an epigenetic modification that essentially silences genes that would normally regulate cell growth and differentiation.
  • Transcriptional repression involves proteins that directly or indirectly bind to DNA, effectively turning off the copying or expression of specific genes or sets of genes. This disruption of normal gene expression pathways is a key factor in the development and progression of MDS and AML.
  • ACOZACIT INJECTION, in its active form, interacts with both RNA and DNA. This interaction disrupts the normal function of these nucleic acids, particularly within rapidly dividing cells. By interfering with RNA and DNA activity, ACOZACIT INJECTION exerts a toxic effect specifically on cancerous cells, ultimately hindering their proliferation and leading to cell death.
  • Specifically, ACOZACIT INJECTION gets integrated into the DNA, forms covalent adducts and inhibits DNA methyltransferases (DNMTs). These are enzymes involved in DNA methylation. By inhibiting DNMTs, ACOZACIT INJECTION can lead to demethylation and reactivation of tumor suppressor genes that are silenced in cancer cells.

How to use ACOZACIT INJECTIONArrow

  • ACOZACIT INJECTION should only be administered under the direct supervision of a qualified physician or healthcare professional. Self-administration is strongly discouraged. The dosage and frequency of ACOZACIT INJECTION will be determined by your physician based on a thorough assessment of your individual needs, including your height, weight, overall health status, and the specific condition being treated. It is crucial to adhere strictly to the prescribed dosage and administration schedule provided by your physician.
  • ACOZACIT INJECTION is typically administered via subcutaneous injection, which means it is injected under the skin. The preferred injection sites include the thigh, stomach (abdomen), or upper arm. Your healthcare provider will guide you on proper injection techniques, including how to select an appropriate injection site, cleanse the area, and administer the injection safely and effectively. If you are administering the injection yourself (under medical supervision), ensure you fully understand the instructions and follow them meticulously.
  • It is important to rotate injection sites to prevent skin irritation or other localized reactions. Regularly monitoring the injection site for any signs of redness, swelling, pain, or other adverse reactions is also crucial. Report any such reactions to your physician immediately. Do not discontinue ACOZACIT INJECTION without consulting your physician, as abruptly stopping the medication may lead to undesirable consequences.

FAQs

How to use ACOZACIT INJECTION?Arrow

Take ACOZACIT INJECTION only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. ACOZACIT INJECTION is administered under the skin of your thigh, stomach, or upper arm.

Does ACOZACIT INJECTION cause hair loss?Arrow

No, ACOZACIT INJECTION does not cause hair loss even after using it for a prolonged period of time.

How does ACOZACIT INJECTION work?Arrow

ACOZACIT INJECTION binds to RNA and DNA, interrupts their activity in actively multiplying cells, and exhibits a toxic effect on cancer cells.

Is ACOZACIT INJECTION chemotherapy?Arrow

Yes. ACOZACIT INJECTION is chemotherapy, and it is used in the treatment of cancers. It interferes with the cell's DNA synthesis and decreases growth and multiplication (cytotoxic effect).

What are the side effects of ACOZACIT INJECTION?Arrow

The common side effects of ACOZACIT INJECTION are Nausea, vomiting, diarrhea, constipation, tiredness, decreased appetite, rashes, redness of skin, dizziness, joint pain, headache, sore throat and nose.

Is it safe to drive after taking an ACOZACIT INJECTION?Arrow

It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking this medication.

NULL interaction of ACOZACIT INJECTION with other drungsArrow

There is no known interaction of ACOZACIT INJECTION with other drugs.

What advice should I follow while taking ACOZACIT INJECTION?Arrow

Inform the doctor if the patient has any allergy reactions, respiratory problems, kidney, liver, or heart problems, and medication taken for different medical conditions before taking this injection as they worsen the condition. Avoid using this injection if the patient is planning for pregnancy or during pregnancy and in breastfeeding mothers as this medicine causes harmful effects in the developing baby. Take this injection only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. It is administered under the skin of your thigh, stomach or upper arm.

What molecule/combination is used for making ACOZACIT INJECTION?Arrow

AZACITIDINE is the molecule/combination used for making ACOZACIT INJECTION.

For which ailments/diseases/conditions is ACOZACIT INJECTION prescribed?Arrow

ACOZACIT INJECTION is prescribed for ailments/diseases/conditions in Oncology.

References

Book Icon

K. Gaston and P.-S. Jayaraman, Transcriptional repression in eukaryotes: Repressors and repression mechanisms, Cellular and Molecular Life Sciences, [May 2003], 60(4):721-741

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Roman M. Shapiro & Alejandro Lazo-Langner, Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia, BMC Hematology, 2018

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Dr.Reddy’s Laboratories

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Marketer / Manufacturer Details

ACCORD PHARMA

Country of Origin -

India

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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