AZAKEM 100MG INJECTION
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AZAKEM 100MG INJECTION
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AZAKEM 100MG INJECTION

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AZAKEM 100MG INJECTION

By ALKEM LABORATORIES LIMITED

MRP

4665

₹3769

19.21 % OFF

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Product DetailsArrow

About AZAKEM 100MG INJECTION

  • AZAKEM 100MG INJECTION is a medication specifically indicated for the treatment of adults diagnosed with Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML), particularly when these individuals are deemed unsuitable candidates for stem cell transplantation. This determination is typically made after a thorough evaluation of the patient's overall health, disease stage, and potential risks associated with a stem cell transplant.
  • Myelodysplastic Syndrome (MDS) is a group of disorders characterized by the bone marrow's inability to produce sufficient quantities of healthy, functional blood cells. This deficiency arises from impaired bone marrow function, leading to a compromised ability to generate red blood cells, white blood cells, and platelets at normal levels. Consequently, patients with MDS often experience anemia, increased susceptibility to infections, and bleeding tendencies.
  • Acute Myeloid Leukemia (AML), on the other hand, is an aggressive form of bone marrow cancer. It is characterized by the rapid proliferation and release of incompletely formed, immature blood cells (blasts) into the bloodstream. These abnormal cells crowd out healthy blood cells, disrupting normal blood cell production and leading to various complications, including fatigue, infections, and bleeding.
  • AZAKEM 100MG INJECTION works by helping to restore normal blood cell production and slow down the progression of the disease. It is administered via injection and the dosage and frequency are determined by the treating physician based on individual patient needs and treatment protocols. Regular monitoring of blood counts and other relevant parameters is essential during treatment to assess the medication's effectiveness and manage any potential side effects.

Uses of AZAKEM 100MG INJECTION

  • Treatment of Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Hematopoietic stem cell transplant, focusing on supportive care and disease management strategies to improve overall outcomes and quality of life.
  • Intermediate-2 and High-risk Myelodysplastic Syndrome (MDS), requiring careful monitoring and tailored treatment approaches to address the specific challenges and potential complications associated with these conditions.

Side Effects of AZAKEM 100MG INJECTIONArrow

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

  • Unexpected bleeding, with blood in stool and urine
  • Fever
  • Pneumonia, characterized by chest pain or breathlessness.
  • Allergic reaction with symptoms of swelling of lips, itching or rashes.
  • Seizures, loss of consciousness, severe headache or bleeding in the brain
  • Frequent urination with pain or burning sensation
  • Disturbances in the blood count (RBC, WBC, Platelets)
  • Nausea, vomiting, diarrhea
  • Constipation
  • Tiredness
  • Skin reactions like redness and pain at the site of injection
  • Decreased appetite
  • Dizziness
  • Pain in extremities
  • Joint pain
  • Stomach pain
  • Headache
  • Sore nose and throat
  • Rashes and bruising

Safety Advice for AZAKEM 100MG INJECTIONArrow

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Pregnancy

UNSAFE

AZAKEM 100MG INJECTION could be harmful to the unborn fetus. Inform your physician if you are pregnant or planning to get pregnant.

Dosage of AZAKEM 100MG INJECTIONArrow

  • AZAKEM 100MG INJECTION should only be administered under the direct supervision of a qualified physician or healthcare professional. Self-administration is strongly discouraged due to the potential for complications and the need for careful monitoring.
  • The appropriate dosage of AZAKEM 100MG INJECTION will be determined by your physician, who will take into account various factors such as your height, weight, overall health condition, and the specific medical condition being treated. It is crucial to adhere strictly to the dosage prescribed by your physician.
  • AZAKEM 100MG INJECTION is typically administered via subcutaneous injection, which means it is injected under the skin. Common injection sites include the thigh, stomach (abdomen), or upper arm. Your physician or a trained healthcare provider will demonstrate the correct injection technique and advise you on rotating injection sites to minimize skin irritation.
  • It is important to follow all instructions provided by your healthcare team regarding the preparation and administration of AZAKEM 100MG INJECTION. If you have any questions or concerns, do not hesitate to ask your physician or pharmacist for clarification.

How to store AZAKEM 100MG INJECTION?Arrow

  • Keep AZAKEM 100MG INJ away from the reach of children and pets.
  • Store AZAKEM 100MG INJ at room temperature.

Benefits of AZAKEM 100MG INJECTIONArrow

  • In both Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML), the uncontrolled growth of tumor cells stems from a process known as transcriptional repression. This repression occurs due to the hypermethylation of DNA, which essentially silences critical genes that regulate cell growth and differentiation. Transcriptional repression involves proteins that bind to DNA, either directly or indirectly, and interfere with the normal process of copying specific genes or sets of genes. This interference disrupts the cell's ability to produce essential proteins, leading to abnormal cell behavior and proliferation. AZAKEM 100MG INJECTION works by actively targeting and disrupting the activity of RNA and DNA within rapidly multiplying cells. This active form of the medication interacts with these nucleic acids, inhibiting their function and ultimately exerting a toxic effect specifically on cancer cells.
  • The drug's mechanism of action helps to normalize the methylation patterns of DNA, reversing the silencing of tumor suppressor genes. This can lead to the restoration of normal cellular functions, including controlled cell growth and programmed cell death (apoptosis) in cancerous cells. By targeting the DNA and RNA of rapidly dividing cells, AZAKEM 100MG INJECTION selectively inhibits the growth and spread of cancerous cells while minimizing damage to healthy cells. This makes it a valuable treatment option for patients battling MDS and AML.
  • Furthermore, AZAKEM 100MG INJECTION plays a crucial role in promoting cellular differentiation, guiding immature blood cells to mature into functional cells. This is particularly important in MDS, where the bone marrow fails to produce healthy blood cells. By encouraging differentiation, the medication can improve blood cell counts and alleviate symptoms associated with the disease.

How to use AZAKEM 100MG INJECTIONArrow

  • It is crucial to receive AZAKEM 100MG INJECTION strictly under the guidance and supervision of a qualified physician. Self-administration is strongly discouraged, as your physician possesses the expertise to determine the most appropriate dosage based on your individual needs.
  • The precise dose of AZAKEM 100MG INJECTION will be carefully calculated by your physician, taking into account several key factors such as your height, weight, overall health condition, and the specific medical condition being treated. This personalized approach ensures that you receive the optimal amount of medication for the best possible outcome.
  • AZAKEM 100MG INJECTION is administered via subcutaneous injection, meaning it is injected under the skin. Your physician or a trained healthcare professional will typically administer the injection into areas such as the thigh, stomach, or upper arm. These locations provide suitable sites for subcutaneous administration and allow for effective absorption of the medication.
  • The injection site will be carefully cleaned and prepared before administering AZAKEM 100MG INJECTION. Following the injection, it's important to follow your physician's instructions regarding any necessary aftercare. If you experience any discomfort or notice any unusual reactions at the injection site, be sure to inform your physician promptly.

FAQs

How to use AZAKEM 100MG INJECTION?Arrow

Take AZAKEM 100MG INJECTION only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. AZAKEM 100MG INJECTION is administered under the skin of your thigh, stomach, or upper arm.

Does AZAKEM 100MG INJECTION cause hair loss?Arrow

No, AZAKEM 100MG INJECTION does not cause hair loss even after using it for a prolonged period of time.

How does AZAKEM 100MG INJECTION work?Arrow

AZAKEM 100MG INJECTION binds to RNA and DNA, interrupts their activity in actively multiplying cells, and exhibits a toxic effect on cancer cells.

Is AZAKEM 100MG INJECTION chemotherapy?Arrow

Yes. AZAKEM 100MG INJECTION is chemotherapy, and it is used in the treatment of cancers. It interferes with the cell's DNA synthesis and decreases growth and multiplication (cytotoxic effect).

What are the side effects of AZAKEM 100MG INJECTION?Arrow

The common side effects of AZAKEM 100MG INJECTION are nausea, vomiting, diarrhea, constipation, tiredness, decreased appetite, rashes, redness of skin, dizziness, joint pain, headache, sore throat and nose.

Is it safe to drive after taking an AZAKEM 100MG INJECTION?Arrow

It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking this medication.

Does AZAKEM 100MG INJECTION interact with other drugs?Arrow

NULL interaction of AZAKEM 100MG INJECTION with other drungs

What precautions should I take while taking AZAKEM 100MG INJECTION?Arrow

Inform the doctor if the patient has any allergy reactions, respiratory problems, kidney, liver, or heart problems, and medication taken for different medical conditions before taking this injection as they worsen the condition. Avoid using this injection if the patient is planning for pregnancy or during pregnancy and in breastfeeding mothers as this medicine causes harmful effects on the developing baby. Take this injection only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight, and general condition. It is administered under the skin of your thigh, stomach, or upper arm.

What is AZAKEM 100MG INJECTION made of?Arrow

AZAKEM 100MG INJECTION is made using AZACITIDINE.

For what ailments/diseases/conditions is AZAKEM 100MG INJECTION prescribed?Arrow

AZAKEM 100MG INJECTION is prescribed for ailments/diseases/conditions related to Oncology.

References

Book Icon

K. Gaston and P.-S. Jayaraman, Transcriptional repression in eukaryotes: Repressors and repression mechanisms, Cellular and Molecular Life Sciences, [May 2003], 60(4):721-741

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Roman M. Shapiro & Alejandro Lazo-Langner, Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia, BMC Hematology, 2018

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Dr.Reddy’s Laboratories

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Marketer / Manufacturer Details

ALKEM LABORATORIES LIMITED

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India

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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