VORTUXI 500MG INJECTION
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VORTUXI 500MG INJECTION
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VORTUXI 500MG INJECTION

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VORTUXI 500MG INJECTION

By ZYDUS LIFESCIENCES LIMITED

MRP

34415.5

₹16402

52.34 % OFF

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Product DetailsArrow

Content Reviewed By:

Dr. Anil Gupta

, (MBBS)

Written By:

Mr. Ankit Jain

, (B.Pharm)

About VORTUXI 500MG INJECTION

  • VORTUXI 500MG INJECTION contains the active ingredient rituximab. It is prescribed for various conditions in adults, either alone or in combination with other medications. Primarily, it treats non-Hodgkin's lymphoma, a cancer affecting B-lymphocytes (a type of white blood cell), and chronic lymphocytic leukemia, a common cancer affecting B-cells. Additionally, it's used in conjunction with methotrexate to manage moderate-to-severe rheumatoid arthritis, an autoimmune disease where the immune system attacks the body's joints. VORTUXI is also indicated for treating granulomatosis with polyangiitis and microscopic polyangiitis, both inflammatory conditions of blood vessels primarily affecting the lungs and kidneys, in both adults and children aged two years and older. Furthermore, it addresses moderate to severe pemphigus vulgaris, an autoimmune disorder characterized by painful blisters on the skin and mucous membranes of the mouth, throat, nose, and genitals.
  • VORTUXI 500MG INJECTION belongs to a class of medications known as anti-CD20 monoclonal antibodies. It's crucial to avoid this injection if you have a known allergy to rituximab or any of its other components, if you have a weakened immune system, or if you are currently experiencing a severe active infection. Before starting treatment, inform your doctor if you have a history of heart disease, heart failure, or breathing difficulties. If you've ever had a hepatitis B infection, discuss this with your doctor, as rituximab can reactivate the infection, potentially leading to severe complications. Pregnancy and breastfeeding are generally not recommended while using this injection. Effective contraception is necessary during treatment and for 12 months after the last dose.
  • Common side effects associated with VORTUXI 500MG INJECTION include blood infections, reduced red blood cell count, dizziness, swelling in the face and body, itchy skin, diarrhea, increased sweating, and fluctuations in blood pressure (either low or high). If you are capable of becoming pregnant, it is imperative to use effective birth control methods during treatment and for a full 12 months following your last dose of VORTUXI. This medication has the potential to cause severe infusion reactions, either during or within 24 hours after administration. It is critical to immediately inform your physician or another healthcare professional if you experience any signs of an infusion reaction, such as elevated blood pressure, chest pain, headache, difficulty breathing, vomiting, skin rashes, or swelling of the throat.

Uses of VORTUXI 500MG INJECTION

  • Non-Hodgkin's lymphoma (NHL) is a type of cancer that begins in the lymphatic system. It involves the abnormal growth of lymphocytes. VORTUXI 500MG INJECTION is often part of the treatment.
  • Chronic lymphocytic leukemia (CLL) is a type of cancer of the blood and bone marrow. It progresses more slowly than other leukemias. VORTUXI 500MG INJECTION can be used to treat CLL.
  • Rheumatoid arthritis is a chronic inflammatory disorder affecting many joints. It can cause painful swelling. VORTUXI 500MG INJECTION is prescribed for some cases of Rheumatoid Arthritis when other treatments aren't sufficient.
  • Granulomatosis with polyangiitis and microscopic polyangiitis are rare autoimmune diseases that cause inflammation of blood vessels. VORTUXI 500MG INJECTION can help manage these conditions.
  • Pemphigus vulgaris is a rare autoimmune disorder that causes painful blisters on the skin and mucous membranes. VORTUXI 500MG INJECTION can be used as a treatment option.

Side Effects of VORTUXI 500MG INJECTIONArrow

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

  • Swelling in the face and body
  • Diarrhea and nausea
  • Itchy skin
  • Anemia
  • Muscle spasm
  • Headache
  • Urinary tract infection
  • Fever, chills, and shivering
  • Inflammation of nasal cavities
  • Cough, sore throat
  • Loss of hair
  • Increased or decreased blood pressure
  • Chest pain
  • Hypersensitivity reactions
  • Hepatitis B viral infection
  • Memory loss, trouble thinking, difficulty in walking

Safety Advice for VORTUXI 500MG INJECTIONArrow

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Pregnancy

UNSAFE

VORTUXI 500MG INJECTION is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for 12 months after your last dose is necessary.

Dosage of VORTUXI 500MG INJECTIONArrow

  • VORTUXI 500MG INJECTION should only be administered by a qualified healthcare professional, such as a trained doctor or nurse. Self-administration of this injection is strictly prohibited. Prior to receiving VORTUXI 500MG INJECTION, you will likely be given pre-medications to help minimize potential side effects. Your doctor will determine the appropriate dosage and duration of your treatment, taking into account the severity of your condition and other relevant individual factors.
  • The administration of VORTUXI 500MG INJECTION will be performed as an intravenous infusion, allowing for careful monitoring throughout the process to promptly address any unwanted side effects that may arise. The healthcare provider will closely observe you during and after the infusion to ensure your safety and well-being. It's crucial to communicate any discomfort or unusual symptoms you experience during the procedure to the medical staff immediately.
  • The dosage regimen is highly individualized and depends on various factors, including your specific diagnosis, overall health status, and response to treatment. Do not attempt to alter the prescribed dosage or frequency of administration without consulting your doctor. Adhering to the recommended treatment plan is essential for achieving the best possible outcomes and minimizing the risk of complications. Remember to discuss any concerns you have regarding your treatment with your healthcare provider.

How to store VORTUXI 500MG INJECTION?Arrow

  • Keep VORTUXI 500MG INJ 50ML away from the reach of children and pets.
  • Store VORTUXI 500MG INJ 50ML in a refrigerator (2 - 8°C). Do not freeze.

Benefits of VORTUXI 500MG INJECTIONArrow

  • VORTUXI 500MG INJECTION is a targeted therapy that works by specifically binding to the CD20 antigen found on the surface of B-lymphocytes. These B-cells are a type of white blood cell that plays a crucial role in certain conditions like Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL).
  • Once VORTUXI 500MG INJECTION attaches to the B-cell, it triggers a process that leads to the death of these cells. This is a key mechanism in treating NHL and CLL, as it helps to reduce the number of cancerous B-cells in the body. By eliminating these cells, the medication can help control the progression of the disease and improve patient outcomes.
  • In addition to its direct effect on B-cells, VORTUXI 500MG INJECTION also has immunomodulatory effects, particularly relevant in rheumatoid arthritis. It can inhibit the production of rheumatoid factor, reduce antigen presentation, suppress T-cell activation, and decrease the production of pro-inflammatory cytokines. These actions help to alleviate the inflammation and joint damage associated with rheumatoid arthritis, providing relief from symptoms and improving quality of life.

How to use VORTUXI 500MG INJECTIONArrow

  • VORTUXI 500MG INJECTION must be administered exclusively by a qualified healthcare professional, such as a doctor or nurse, who has received comprehensive training in its use. Self-administration is strictly prohibited. Prior to receiving VORTUXI 500MG INJECTION, you will be given premedications to minimize the potential for side effects. These premedications are carefully selected to help manage any adverse reactions that may arise during or after the infusion.
  • The dosage and duration of your treatment with VORTUXI 500MG INJECTION will be determined by your doctor, taking into account the severity of your condition and other individual factors. It's crucial to adhere to your doctor's prescribed regimen for optimal results. This medication is administered as an intravenous infusion, allowing it to be delivered directly into your bloodstream.
  • Throughout the infusion process, you will be closely monitored by healthcare professionals to detect any potential side effects. This vigilant monitoring ensures that any adverse reactions are promptly identified and managed, prioritizing your safety and well-being. Your medical team is dedicated to providing the best possible care and will address any concerns you may have during the treatment.

FAQs

What are the special precautions I should be aware of before starting treatment with VORTUXI 500MG INJECTION?Arrow

Inform your doctor about your pre-existing conditions (heart, kidney, liver, hepatitis B, or lung disease) and vaccination history. It is necessary to consult a doctor if you are taking medicines for blood pressure.

What are VORTUXI 500MG INJECTION-related reactions?Arrow

Infusion reactions occur during or within 24 hours after administering VORTUXI 500MG INJECTION. The symptoms are fever, chills, cough, itchy skin, nausea, vomity, flushing, increased heart rate, and discomfort in the throat. Inform your physician immediately if you face any infusion-related reaction.

What will be the most important thing to monitor during VORTUXI 500MG INJECTION?Arrow

Your healthcare professional will monitor you carefully for unwanted side effects during the VORTUXI 500MG INJECTION. You will be monitored for heart failure, increased blood pressure, or breathing failure.

Does VORTUXI 500MG INJECTION suppress the immune system?Arrow

Yes, can suppress the immune system, and the chances of catching an infection are high. Inform your doctor if you have a severe active infection before taking VORTUXI 500MG INJECTION because it may cause drug-induced immunosuppression.

Is weight gain a side effect of VORTUXI 500MG INJECTION?Arrow

Weight gain has been reported in patients treated with VORTUXI 500MG INJECTION for non-hodgkin’s lymphoma.

Is there any drug interaction with VORTUXI 500MG INJECTION?Arrow

There is no known drug interaction with VORTUXI 500MG INJECTION.

What advice should I be given for VORTUXI 500MG INJECTION?Arrow

Avoid vaccines before and during therapy. Inform your physician if you have been vaccinated recently because VORTUXI 500MG INJECTION may cause drug-induced immunosuppression. Report to your doctor immediately if you face any symptoms like chest pain, breathing difficulties, stomach pain, and skin reactions. There is limited information available on the safety of this medicine in renal failure patients; inform your physician if you have kidney disease. Vaccination with live virus vaccines is not recommended before or during the treatment for patients with rheumatoid arthritis. Inform your healthcare professional if you have any active infection during the treatment.

Which molecule/combination is used for making VORTUXI 500MG INJECTION?Arrow

RITUXIMAB is molecule/combination used for making VORTUXI 500MG INJECTION.

For which ailments/diseases/conditions is VORTUXI 500MG INJECTION prescribed?Arrow

VORTUXI 500MG INJECTION is prescribed for ailments/diseases/conditions like Oncology, Gastroenterology, Rheumatology, Orthopaedics.

References

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HIGHLIGHTS OF PRESCRIBING INFORMATION. (2021).

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ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS. (2020).

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Marketer / Manufacturer Details

ZYDUS LIFESCIENCES LIMITED

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India

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52.34 % OFF

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Medkart's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, medicines, generic alternatives, all possible side effects, drug interactions, warnings, alerts, lab tests, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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